Gretchen MahlerGretchen Mahler

Assistant Professor, Department of Bioengineering

Research Interests: In vitro and in silico toxicology and pharmacology, microfluidic models of organs and tissues, endothelial and epithelial cell pathobiology.
Phone: 607-777-5238
Office: Room 2608

gmahler@binghamton.edu

 

Research Focus

Our lab uses microfluidics and 3D scaffolds to create physiologically realistic cell culture models of organs and tissues. These in vitro models can be engineered to signal cells using biochemical and biomechanical pathways, help to minimize animal testing, and provide tightly controlled, reproducible experimental conditions. The goal of our work is to replicate some of the cell-cell and cell-extracellular matrix interactions not easily studied in vivo or in silico to better understand how cells behave during disease and respond to chemicals or drugs. Our current research has applications toward cardiovascular disease and cancer and focuses on how disruptions in a tissue's local mechanical environment can lead to changes in cell phenotype and disease initiation and progression.

Education

Postdoctoral Fellow-Biomedical Engineering, Cornell University, Ithaca, NY, 2008-2011

Ph.D.-Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 2008

B.S.-Chemical Engineering, University of Massachusetts Amherst, Amherst, MA, 2002

Academic Appointments

Assistant Professor- Bioengineering, Binghamton University, Binghamton, NY, 2011-present

Honors & Awards

2008   The Hartwell Foundation Postdoctoral Fellowship

2007   Cornell University Department of Chemical and Biomolecular Engineering Hooey Prize

2002   University of Massachusetts Amherst Senior Leadership Award

2002   UMass Alumni Association Research Scholarship

2001   Tau Beta Pi Honor Society

2000   Hamilton Sundstrand Summer Internship Award

Relevant Publications

Mahler GJ, Farrar EJ, and Butcher JB. Inflammatory cytokines promote mesenchymal transformation in embryonic and postnatal valve endothelial cells. 2011; Submitted.

Mahler GJ, EschMB, Tako E, SouthardTL, ArcherSD, GlahnRP, and Shuler, ML. Oral exposure to polystyrene nanoparticles effects iron absorption. 2011; Submitted.

Mahler GJ and Butcher JT. Cardiac developmental toxicity. Birth Defects Research Part C: Embryo Today: Reviews. 2011; In press.

Mahler GJ and Butcher JT. Inflammatory Regulation of Valvular Remodeling: The Good(?), the Bad, and the Ugly. International Journal of Inflammation. 2011; Article ID 721419, doi:10.4061/2011/721419.

Butcher JT, Mahler GJ, and Hockaday LA. Aortic valve disease and treatment: The need for naturally engineered solutions. Advanced Drug Delivery Reviews. 2011; 63(4-5): 242-268.

Mahler GJ, Gould RA, and Butcher JT. Isolation and culture of avian embryonic valvular progenitor cells. Journal of Visualized Experiments. 2010; 44: http://www.jove.com/index/details.stp?id=2159, doi: 10.3791/2159.

Chiu YN, Norris RA, Mahler GJ, Gould RA, Recknagel AK, and Butcher JB. Complementary and redundant roles for TGFb3, BMP2, and VEGFA in embryonic atrioventricular valve remodeling. Tissue Engineering Part A. 2010; 16(11): 3375-3383.

Mahler GJ, Esch MB, Glahn RP, and Shuler ML. Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnology and Bioengineering. 2009; 104(1): 193-205.

Mahler GJ, Shuler ML, and Glahn, RP. Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. Journal of Nutritional Biochemistry. 2009; 20(7): 494-502.

McAuliffe GJ, Chang JY, Glahn RP, and Shuler ML. Development of a gastrointestinal tract microscale cell culture analog to predict drug transport. Molecular and Cellular Biomechanics. 2008; 5(2):119-32.

Shuler ML, McAuliffe GJ, and Tatosian DA. Animal surrogate systems for toxicity testing In Encyclopedia of Biomaterials and Biomedical Engineering. G. Wnek and G. Bowlin, Eds. New York: Marcel Dekker, Inc., March 27, 2006. 1-10.

McAuliffe GJ, Roberts L, and Roberts S. The influence of environmental conditions on the encapsulation of HepG2 liver cells in alginate. Journal of Undergraduate Research in Bioengineering. 2003; 3(1): 70-75.

McAuliffe GJ, Roberts L, and Roberts S. Paclitaxel administration and its effects on clinically relevant human cancer and non cancer cell lines. Biotechnology Letters. 2002; 24(12): 959-964.

Last Updated: 1/15/14