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Dennis W. McGee

Dennis W. McGee

Professor of Biological Sciences

BA, MS, University of New Orleans
PhD, Texas A&M University

Office: Science III - 148
Phone: 607-777-2620

Research Interests:

Intestinal Epithelial Cell Biology & Immunology

As a mucosal immunologist, my research focuses on the role of intestinal epithelial cells (IEC) in the intestinal immune response. IEC can secrete several cytokines, such as IL-6, IL-8 and MCP-1, which enhance or suppress both the immune and inflammatory responses. We are  examining novel mechanisms, including integrin-extracellular matrix interactions, which regulate IEC production of these cytokines, including the effect on intracellular signaling pathways which regulate cytokine production (e.g. IkBa/NF-kB and JNK/AP-1 pathways). It is our hope that these studies will not only help to define the defense mechanisms at the intestinal mucosa, but also provide some possible avenues whereby disease treatments or vaccines may utilize the regulatory effects of the IEC.

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Last Updated: 2/23/15