Associate Professor Biological Sciences
BS, University of Pennsylvania, Edinboro
MS, Duquesne University
PhD, Ohio State University
Office: Science III - 220
Eukaryotic gene expression and signal transduction
The research in my lab centers around two foci; the molecular signaling associated with early events in programmed cell death (PCD), and cell cycle regulation in arthropod dormancy.
1. Signal transduction in mammalian neuron apoptosis. Neurodegenerative diseases such as Alzheimer's Disease, ALS, and Parkinson's Disease are the result of untimely neuronal apoptosis. One necessary event that triggers the neuron towards apoptosis is the generation of reactive oxygen species (ROS). However, the enzyme(s) responsible for this ROS production are currently unknown. We are investigating several enzymes known to generate ROS in order to elucidate their potential role(s) in neuronal degeneration. From these studies, we ultimately hope to isolate enzymes that may be used as targets in treatment modalities.
2. Cell cycle regulation in arthropod dormancy. Many arthropods overcome the harsh conditions of winter in a hibernation-like state called diapause. It is a period of decreased metabolism that is expressed as a developmental arrest for up to several months. We are currently studying the role of cell cycle regulation genes as the controlling factor(s) of diapause in a wide range of arthropods, including flies, moths, other insects and ticks.
Last Updated: 2/4/11