Brian Callahan

Dr. Brian P. Callahan

Assistant Professor of Biological Chemistry

  • B.S., State University of New York, Cortland, 1996
  • Ph.D., University of North Carolina, Chapel Hill, 2005
Science 2 Bldg - Room 328
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Research Interests:

We investigate the chemical biology of protein biogenesis and protein degradation, two essential events in the expression of genetic information. Our research in this area is technology and hypothesis driven, with applications to major human diseases such as tuberculosis and cancer.

Recent Selected Publications

Bordeau BM, Ciulla DA, Callahan BP. Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer. ChemMedChem. 2016 11, 1983–1986

Xie J, Owen T, Xia K, Callahan B, Wang C., A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing, J Am Chem Soc. 2016 138, 10806-9

Callahan BP, Wang C. Hedgehog cholesterolysis: specialized gatekeeper to oncogenic signaling. Cancers (Basel). 2015 7, 2037-53.

Owen, T.S.; Ngoje, G.; Lageman, T.J.; Bordeau, B.M.; Belfort M.; Callahan B.P. Förster Resonance Energy Transfer-based Cholesterolysis Assay Identifies a Novel Hedgehog Inhibitor. Anal. Biochem. 2015 488, 1-5

Xie J.; Owen T.; Xia K.; Singh A.V.; Tou E.; Li L.; Arduini B.; Li H.; Wan L.Q.; Callahan B.; Wang C.  Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J. Biol. Chem. 2015, 290, 11591-600.

Owen, T.S.; Xie, X.J.; Laraway B.; Ngoje G.; Wang C.; Callahan B.P. Active site targeting of hedgehog precursor protein with phenylarsine oxide. Chembiochem. 2015, 16, 55-8.

Last Updated: 9/22/16