Active Alert: Classes canceled rest of today and tomorrow

B-ALERT:Due to forecast, all classes effective 4:30pm today Nov 25 are canceled. There will be no classes Wednesday Nov 26. Adjust travel plans accordingly.

Alert updated: Tuesday, November 25, 2014 3:50 PM

Brian Callahan

Dr. Brian P. Callahan

Assistant Professor of Biological Chemistry

  • B.S., State University of New York, Cortland, 1996
  • Ph.D., University of North Carolina, Chapel Hill, 2005
Science 2 Bldg - Room 326
Web page:

Research Interests:

We investigate the chemical biology of protein biogenesis and protein degradation, two essential events in the expression of genetic information. Our research in this area is technology and hypothesis driven, with applications to major human diseases such as tuberculosis and cancer.

Recent Selected Publications

Callahan B.P.; Stanger M.; Belfort M. A redox trap to augment the intein toolbox. Biotechnol Bioeng. 2013, 110, 1565-73.

Xie J.; Du Z.; Callahan B.; Belfort M.; Wang C. (1)H, (13)C, and (15)N NMR assignments of a Drosophila Hedgehog autoprocessing domain. Biomol NMR Assign. 2013, Jun 14.

Dearden A.K.; Callahan B.; Roey P.V.; Li Z.; Kumar U.; Belfort M.; Nayak S.K. A conserved threonine spring-loads precursor for intein splicing. Protein Sci. 2013, May 22(5), 557-63.

Callahan B.P.; Topilina, N.; Stanger M.; Van Roey P.; Belfort M. Structure of a catalytically competent intein caught in a redox trap with functional and biological implications. Nat. Struct. Mol. Biol. 2011, 18, 630-3.

Callahan B.P.; Stanger M.; Belfort M. Protease activation of split green fluorescent protein. ChemBioChem 2010, 11, 2259-63.

Amitai G.; Callahan B.P.; Stanger M.; Belfort G.; Belfort M. Modulation of intein activity by its neighboring extein substrates. Proc. Natl. Acad. Sci. USA 2009, 106, 11005-10.

Callahan B.P.; Yaun, Y.; Wolfenden R. The burden borne by urease. J. Am. Chem. Soc. 2005, 127, 10828-9. (Highlighted in Science)

Last Updated: 6/25/14