Managing a large class can be challenging, even for the most experienced instructor. The Center for Learning and Teaching offers support for faculty [and TAs?] involved with high-enrollment classes and large lecture situations. Personalized course consultations are available [link to Instructional design & course consultation page, above]. Please also check the resources below and in the CLT Teaching Resource Guide.
The Tomorrow's Professor website has hundreds of brief articles about all aspects of academic life. Go to http://cgi.stanford.edu/~dept-ctl/cgi-bin/tomprof/postings.php# and enter "Large Lecture" in the search field.