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A MULTI-UNIVERSITY COLLABORATIVE VENTURE

News & Events

International Society for Developmental Psychobiology (ISDP)
November 12-14, 2014
Washington, D.C.
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Society for Neuroscience (SfN)
November 15-19, 2014
Washington, D.C.
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Research Highlights

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microscope comparison

microscope comparison

microscope comparison

microscope comparison

Pilot Projects

Pilot Project 1: Maternal Care Influence in Offspring Ethanol Sensitivity

PI: Nicole M. Cameron (link to e-mail: ncameron@binghamton.edu)

This study aims to investigate maternal care programming of alcohol use in the rat. Specifically, we will study the effects of natural variations in maternal care on sedative/hypnotic effects of alcohol at different doses at postnatal days 30, 50 and 90 in male and female offspring. We will also investigate changes in the γ-aminobutyric acid (GABA) subunit expression in brain regions associated with alcohol sensitivity, such as hippocampus, medial prefrontal cortex and nucleus accubens. Lastly we will use next-generation sequencing to compare the effects of maternal care received on DNA methylation of the promoter region of the GABAA receptor subunits shown to be associated with the variation of sensitivity in our model. This pilot is expected to clarify the role of early life on alcohol sensitivity. It will also improve our understanding of epigenetic programming of the GABAergic system.

Last Updated: 11/3/11