Active in campus theater productions, Reiser founded "The Little Theater That Could", an on-campus community theater organization - now called Hinman Production Company.
Reiser made his feature film debut in Diner in 1982 and later had roles in Beverly Hills Cop, Aliens, Crazy People and Bye, Bye Love. In 1992, he began his most famous role to date as Paul Buchman in the award-winning NBC series Mad About You. A co-creator of the series, Reiser also served as executive producer and writer, and co-wrote the show's theme song.
An accomplished pianist, he has been invited to perform at university campuses and with philharmonic orchestras. He is also the author of two bestsellers, Couplehood (1994) and babyhood (1997). In 1996, Reiser established the Samuel Reiser Scholarship at Binghamton University in honor of his father. He served as honorary co-chair of the University's first comprehensive gifts campaign, and was awarded an honorary doctorate at Commencement in May 2000.
