CHRISTOPHER R. BISHOP
Professor of Psychology
Ph.D., Wayne State University
Post-doctoral training: Wayne State University School of Medicine
Area: Behavioral Neuroscience
Office: Science IV, Room 363
Member of the Society for Neuroscience, the Movement Disorders Society, International Basal Ganglia Society and the Center for Development and Behavioral Neuroscience
Parkinson's Disease, Neuroplasticity, Drug Development.
Movement is an ancient and basic function that is integral to the survival of the individual and species. As such, disorders of movement have a profound impact upon all facets of life. One of the most common movement disorders is Parkinson's disease, a neurodegenerative disorder that compromises dopaminergic areas of the brain rendering the individual unable to initiate, coordinate and execute movement. By employing an animal model of Parkinson's disease and a combination of behavioral, neurochemical and neuroanatomical techniques our laboratory examines the role of various neurotransmitters and neurocircuits responsible for this debilitating disorder. As importantly, we explore pharmacological targets within the brain that may aid in the development of more efficacious treatment for the Parkinsonian patient. Current projects, funded by the National Institute of Neurological Disease and Stroke and the Michael J. Fox Foundation investigate neuroplasticity in the brain serotonin system that may provide a novel target for the reduction of parkinsonian symptoms and side effects that occur as a result of chronic drug therapy.
Philosophy of Graduate Training:
My goal as a mentor is to provide students with the necessary tools, both theoretical and technical, to become productive independent researchers. Throughout the course of graduate curricula and laboratory experience, students will have the opportunity to develop a unique scientific approach and master a number of behavioral, neurochemical and neuroanatomical techniques that will lead to the design, execution and communication of sound and innovative research questions.
Bhide, N., Lindenbach, D., Barnum, C.J., Geroge, J.A., Surrena, M.A. and Bishop, C. (2015). Effects of the beta-adrenergic receptor antagonist Propranolol on dyskinesia and L-DOPA-induced striatal DA efflux in the hemi-parkinsonian rat. Journal of Neurochemistry, 134(2):222-32. (PMID: 25866285).
Ostock, C.Y., Hallmark, J., Palumbo, N., Bhide, N., Conti, M. and Bishop, C. (2015). Modulation of L-DOPA’s antiparkinsonian and dyskinetic effects by α2-noradrenergic receptors within the locus coeruleus. Neuropharmacology 95:215-25. (PMID: 25817388).