Associate Professor of Psychology
Ph.D., City University of New York
Post-doctoral fellowship: Columbia University
(Advisors: Drs. Rae Silver and Ann J. Silverman)
Area: Behavioral Neuroscience
Office: Science IV, Room 251
Member, Society for Neuroscience; Member, American Society for Neural Transplantation; Member, Society for Biological Rhythms Research; Ad Hoc reviewer NSF grant proposals and for various scienticic journals.
Biological rhythms, epilepsy/development, neural transplantation
The long term purpose of this laboratory is to elucidate the neural processes underlying circadian rhythmicity. The experiments are intended to understand neural plasticity and behavioral recovery in the field of biological rhythms as studied by means of fetal grafting. In particular, we are interested in recovery of behavioral functions related to grafting of the hypothalamic region of the brain. Emphasis is placed on the neurochemical and neuroanatomical characteristics of the grafted tissue and the possible interactions between the graft and the host brain.
A second area of interest is related to the differential plasticity of the adult and developing rodent brain following epileptic seizures. Currently we are studying neurodegeneration of hippocampal areas produced by limbic seizures in an attempt to determine the mechanisms mediating resistance to damage in the developing brain.
Philosophy of Graduate Training:
Graduate students are immediately involved in on-going collaborative research projects as a means for introducing them to the issues, methods and joys of research. Students are also strongly encouraged to initiate independent projects in order to explore and develop their ideas. These combined experiences are intended to develop critical thinking and problem solving skills for academic and industry positions.
Sperber, EF., Hass, KZ., Romero, M.-T., Stanton, P.K. and Moshé, S.L. (submitted) Flurothyl status epilepticus in developing rats: Behavioral, electrographic, histological and electrophysiological studies. Epilepsy Research.
Sperber, EF., Germano, IM., Friedman, LK., Veliskova, J and Romero, M-T. (In press) The resiliency of the immature brain to seizure induced damage. In A. Nehlig and J. Motte (Eds.), Childhood Epilepsy and Brain Development. John Libbey & Co.: New York, NY.
Silver, R., Romero M-T., Besmer, H.R., Khan, R., LeSauter, J., Nunez, J.M. (1996) A distinct subregion of calbindin-D28k-like immunoreactive cells in the hamster SCN. Neuroreport, 7, 1224-1228.
Romero, M-T., Silverman, A-J., Wise, P. and Witkin, J. (1994) Ultrastructural changes in GnRH cells as a function of age and ovariectomy in rats. Neuroscience, 58, 217-225
Romero, M-T. Lehman M.N., and Silver, R. (1993) Age of donor influences ability of SCN grafts to restore circadian rhythmicity. Developmental Brain Research, 71, 45-52.