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Ming An

Dr. Ming An

Associate Professor, Organic and Bioorganic Chemistry, Chemical Biology, Biophysics
and Chair of Graduate Recruiting Committee

  • B.S., University of Michigan, Ann Arbor, 1996
  • Ph.D., University of California, Berkeley, 2003
Smart Energy Bldg - Room 1019
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Research Interests:

My research interests are in the general areas of organic, bio-organic, medicinal, biological, and pharmaceutical chemistry, as well as chemical biology and drug discovery.

Selected Publications

Otieno, S. A.; Hanz, S. Z.; Chakravorty, B.; Zhang, A.; Klees, L. M.; An, M.; Qiang, W.; "pH-dependent Thermodynamic Intermediates of pHLIP Membrane Insertion Determined by Solid-state NMR Spectroscopy" Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 12194-12199. doi: 10.1073/pnas.1809190115.

Zhang, A.; Yao, L.; An, M.; "Reversing the Undesirable pH-profile of Doxorubicin via Activation of di-substituted Maleamic Acid Prodrug at Tumor Acidity" Chemical Communications, 2017, 53, 12826.

Osonga, F. J.; Onyango, J. O.; Mwilu, S. K.; Noah, N. M.; Schulte J.; An, M.; Sadik, O. A.; “Synthesis and Characterization of Novel Flavonoid Derivatives via Sequential Phosphorylation of Quercetin” Tetrahedron Lett., 2017, 58, 1474-1479.

Hanz, S. Z.; Shu, N. S.; Qian, J.; Christman, N.; Kranz, P.; An, M.; Grewer, C.; Qiang, W.; “Protonation-driven membrane insertion of the pH-low insertion peptide” Angew. Chem. Int. Ed., 2016, 55, 12376 –12381. DOI:10.1002/anie.201605203.

Shu, N. S.; Chung, M. S.; Yao, L.; An, M.; Qiang, W.; “Residue-specific Structures and Membrane Locations of the pH-Low Insertion Peptide by Solid-state NMR Spectroscopy” Nature Communications, 2015, 6, 7787. doi: 10.1038/ncomms8787.

Onyango, J. O.; Chung, M. S.; Eng, C.-H.; Klees, L. M.; Langenbacher, R.; Yao, L.; An, M.; “Noncanonical Amino Acids Improve the pH-response of pHLIP Insertion at Tumor Acidity” Angew. Chem. Int. Ed. 2015, 54, 3658-3663.

Karabadzhak, A. G.; An, M.; Yao, L.; Langenbacher, R.; Moshnikova, A.; Adochite, R.; Andreev, O. A.; Reshetnyak, Y. K.; and Engelman, D. M.; “pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo” ACS Chem. Biol., 2014, 9, 2545-2553

An, M.; Wijesinghe, D.; Andreev, O.; Reshetnyak, Y.; and Engelman, D. M.; “pHLIP Translocation of Membrane Impermeable Phalloidin Toxin Inhibits Cancer Cell Proliferation” Proc. Natl. Acad. Sci. U.S.A., 2010, 107, 20246-20250.

Thevenin, D.; An, M.; and Engelman, D. M.; “pHLIP-Mediated Translocation of Membrane-Impermeable Molecules into Cells” Chemistry & Biology, 2009, 16, 754-762.

Jin, J.; An, M.; Sapienza, A.; Aiyar, N.; Naselsky, D.; Sarau, H. M.; Foley, J. J.; Salyers, K. L.; Knight, S. D.; Keenan, R. M.; Rivero, R. A.; Dhanak, D.; Douglas, S. A.; "Urotensin-II Receptor Antagonists: Synthesis and SAR of N-Cyclic Aza-alkyl Benzamides" Bioorg. Med. Chem. Lett. 2008, 18, 3950-3954.

An, M. and Bartlett, P. A.; "Enzymatic Synthesis of a Ring Contracted Analogue of 5-Enolpyruvylshikimate-3-Phosphate" Org. Lett. 2004, 6, 4065-4067.

An, M.; Maitra U.; Neidlein, U. and Bartlett, P. A.; “5-Enolpyruvylshikimate-3-Phosphate Synthase: Chemical Synthesis of the Tetrahedral Intermediate and Assignment of the Stereochemical Course of the Enzymatic Reaction” J. Am. Chem. Soc., 2003, 125, 12759-12767.

An, M.; Toochinda, T. and Bartlett, P. A.; "Five-Membered Ring Analogues of Shikimic Acid" J. Org. Chem. 2001, 66, 1326-1333.

Last Updated: 1/17/19