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Brian Callahan

Dr. Brian P. Callahan

Associate Professor of Biological Chemistry

  • BS, State University of
    New York, Cortland, 1996
  • PhD, University of North
    Carolina, Chapel Hill, 2005

Office: Smart Energy bldg - room 1047
Phone: 607-777-3089
Fax: 607-777-4478
Group page:

Research Interests:

We investigate the chemical biology of protein biogenesis and protein degradation, two essential events in the expression of genetic information. Our research in this area is technology and hypothesis driven, with applications to major human diseases such as tuberculosis and cancer.

Recent Selected Publications

Ciulla DA, Wagner AG, Liu X, Cooper CL, Jorgensen MT, Wang C, Goyal P, Banavali NK, Pezzullo JL, Giner JL, Callahan BP. Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism. Chem Commun (Camb). 2019, 55, 1829-1832.

Ciulla DA, Jorgensen MT, Giner JL, Callahan BP. Chemical Bypass of General Base Catalysis in Hedgehog Protein Cholesterolysis Using a Hyper-Nucleophilic Substrate. J Am Chem Soc., 2018, 140, 916-918. (selected for journal cover)

Li A, Yadav R, White JK, Herroon MK, Callahan BP, Podgorski I, Turro C, Scott EE, Kodanko JJ. Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1. Chem Commun (Camb). 2017, 53, 3673-3676

Bordeau BM, Ciulla DA, Callahan BP. Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer. ChemMedChem. 2016 11, 1983–1986

Xie J, Owen T, Xia K, Callahan B, Wang C., A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing, J Am Chem Soc. 2016 138, 10806-9

Callahan BP, Wang C. Hedgehog cholesterolysis: specialized gatekeeper to oncogenic signaling. Cancers (Basel). 2015 7, 2037-53.

Owen, T.S.; Ngoje, G.; Lageman, T.J.; Bordeau, B.M.; Belfort M.; Callahan B.P. Förster Resonance Energy Transfer-based Cholesterolysis Assay Identifies a Novel Hedgehog Inhibitor. Anal. Biochem. 2015 488, 1-5

Xie J.; Owen T.; Xia K.; Singh A.V.; Tou E.; Li L.; Arduini B.; Li H.; Wan L.Q.; Callahan B.; Wang C.  Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J. Biol. Chem. 2015, 290, 11591-600.

Owen, T.S.; Xie, X.J.; Laraway B.; Ngoje G.; Wang C.; Callahan B.P. Active site targeting of hedgehog precursor protein with phenylarsine oxide. Chembiochem. 2015, 16, 55-8.

Last Updated: 3/21/19