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Christof T. Grewer

Christof T. Grewer

Professor of Biophysical Chemistry

  • Diploma in Chemistry (equivalent to M.S.), Johann Wolfgang Goethe-University, Frankurt, Germany, 1990
  • Ph.D. in Physical Chemistry, Johann Wolfgang Goethe-University, Frankfurt, Germany, 1993
Smart Energy bldg - 1042
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Research Interests:

The long-term goal of our research is to understand the function and the working mechanism of membrane-bound transport proteins. In general, transporters use different types of energy sources to actively move specific substrates, such as inorganic ions or small, organic molecules across the membrane into or out of cells. Recently, significant progress has been made towards our understanding of the molecular architecture through the availability of high-resolution structures of several transporters. However, the actual transport mechanism(s) remain elusive. Our aim is to combine functional and structural evidence in order to obtain an understanding of how these transport proteins work.

Selected Publications

Muse O, Zengeya T, Mwaura J, Hnedzko D, McGee DW, Grewer C, Rozners E., Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates. ACS Chem. Biol, 2013, 16,1683-1686.

Zander CB, Albers T, Grewer C. J., Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2, Gen. Physiol, 2013, 141, 659-672.

Grewer C, Gameiro A, Mager T, Fendler K., Electrophysiological characterization of membrane transport proteins, Annu. Rev. Biophys., 2013, 42, 95-120.

Mwaura J, Tao Z, James H, Albers T, Schwartz A, Grewer C., Protonation state of a Conserved acidic amino acid involved in Na+ binding to the glutamate transporter EAAC1, ACS Chem. Neurosci., 2012, 19, 1073-1083.

Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A., Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter,  J. Biol. Chem.,  2012, 287, 26921-26931.

Albers T, Marsiglia W, Thomas T, Gameiro A, Grewer C., Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs,  Mol. Pharmacol., 2012, 81, 356-365.

Last Updated: 8/10/17