Dr. Wei Qiang
Assistant Professor, Biophysical Chemistry
- B.S., chemistry, Tsinghua University, Beijing, China, 2004
- Ph.D., chemistry, Michigan State University, East Lansing, Michigan, 2009
- Smart Energy bldg - room 1043
- Group page:
My research interests focus on the biological application of the solid-state nuclear magnetic resonance (NMR) spectroscopy. Our current projects include (1) understanding the structural basis and molecular mechanisms of the cellular membrane disruption induced by the early-stage aggregation of beta-amyloid peptides, (2) probing the mechanisms of the pH regulation of the pH-low insertion peptides and their applications in cancer diagnosis and treatment, and (3) designing the structure-specific bio bench markers and/or inhibitors to pathologically important beta amyloid fibrils. In addition to the solid-state NMR spectroscopy, we utilize a combination of approaches including transmission electron microscopy, fluorescence spectroscopy, computational modeling as well as peptide and lipid chemistry.
S.A. Otieno, S.Z. Hanz, B. Chakravorty, A. Zhang, L.M. Klees, M. An, and W. Qiang, pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy, PNAS, 2018, in press.
Q. Cheng, Z.W. Hu, K.E. Doherty, Y.J. Tobin-Miyaji, and W.Qiang, The on-fibrillation-pathway membrane content leakage and off-fibrillation-pathway lipid mixing induced by 40-residue beta-amyloid peptides in biologically relevant model liposomes, BBA-Biomembranes, 2018, 1860(9), 1670-1680.
Q. Cheng, and W. Qiang, Solid-state-NMR-based inhibitor design to achieve selective inhibition of the parallel-in-register beta-sheet versus antiparallel Iowa mutant beta-amyloid fibrils, J. Phys. Chem. B, 2017, 121(122), 5544-5552.
Z.W. Hu, M.R. Ma, Y.X. Chen, Y.F. Zhao, W. Qiang, Y.M. Li, Phosphorylation at Ser8 as an intrinsic regulatory switch to regulate the morphologies and structures of Alzheimer's 40-residue beta-amyloid fibrils, J. Biol. Chem., 2017, 292(7), 2611-2623.
W. Qiang, W.M. Yau, J.X. Lu, J. Collinge, and R. Tycko, Structural variation in amyloid-beta fibrils from Alzheimer's disease clinical subtypes, Nature, 2017, 541, 217-221.
S.Z. Hanz, N.S. Shu, J. Qian, N. Christman, P. Kranz, M. An, C. Grewer, and W. Qiang,
"Protonation-driven membrane insertion of the pH-low insertion peptide", Angew. Chem. Int. Ed., 2016, 55(40), 12376-12381.
D.A. Delgado, K.E. Doherty, Q. Cheng, H. Kim, D. Xu, H. Dong, C. Grewer, and W. Qiang, "Distinct membrane disruption pathways induced by the 40-residue beta-amyloid peptides", J. Biol. Chem., 2016, 291(23), 12233-44.