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Previously Highlighted Publications

 

Vetticat Group

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The honor thesis research of an undergraduate student Vladislav Roytman is the subject of a recent publication in Chem. Eur. J. from the Vetticatt group at Binghamton University. This paper details the use of 13C kinetic isotope effects and DFT calculations as a novel probe to distinguish between of enol and enamine mechanisms in aminocatalysis.

Roytman, V. A.; Karugu, R. W.; Hong, Y.; Hirschi, J. S.; Vetticatt, M. J. 13C Kinetic Isotope Effects as a Quantitative Probe To Distinguish between Enol and Enamine Mechanisms in Aminocatalysis Chem. Eur. J. 2018, 24(32), 8098-8102.

Read more at https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201801748

 


Vetticat Group

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A recent publication in J. Am. Chem. Soc. from the Vetticatt/Hirschi groups at Binghamton University in collaboration with the Lambert group at Cornell University reports on a novel mode of asymmetric induction in chiral Brønsted acid catalysis. Computational exploration of the origin of enantioselectivity reveals a unique point-chirality-induced helical chirality of the catalyst dictates the enantioselectivity of an inverse electron demand Diels Alder reaction.

Citation: Chirag D.; Gheewala, C.D.; Hirschi, J.S.; Lee, W-H.; Paley, D.W.; Vetticatt, M.J. and Lambert, T.H. J. Am. Chem. Soc., 2018, 140(10), 3523-3527

Read more at https://pubs.acs.org/doi/10.1021/jacs.8b00260

 


Rozners Group

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Rozners group in collaboration with Dharmacon, Vandebilt and Rochester researchers recently reported in ACS Chemical Biology that replacement of a single phosphate linkage between the first and second nucleosides of the passenger strand of a short interfering RNA with an amide linkage almost completely abolished its undesired activity and restored the desired activity of guide strands that had been compromised by unfavorable amide modifications. Eliminating off-target activity of the passenger strand will be important for improving therapeutic potential of short interfering RNAs.

Citation: Hardcastle, T., Novosjolova, I., Kotikam, V., Cheruiyot, S. K., Mutisya, D., Kennedy, S. D., Egli, M., Kelley, M. L., Smith, Anja van B., and Rozners, E. A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs. ACS Chem. Biol. 2018, 13, 533-536.

 


Callahan Group

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Congratulations to Dan Ciulla (Callahan group) whose recent paper was featured on the cover of the Journal of the American Chemical Society and featured in the journal's Spotlight section. The paper describes a new approach to control the activity of a cancer-related protein through the combined power of site-directed mutagenesis and mechanism-guided chemical synthesis.

Citation: Ciulla, D.A,; Jorgensen, M.T.; Giner, J.L.; Callahan, B.P. Chemical Bypass of General Base Catalysis in Hedgehog Protein Cholesterolysis Using a Hyper-Nucleophilic Substrate. J Am Chem Soc. 2018, 140(3), 916-918.

 


Grewer Group

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The paper describes the identification of energetic contributions to the substrate translocation by glutamate transporters and highlights the critical contribution of charge compensation to transport, adding to results from previous molecular dynamics simulations for improved understanding of the glutamate translocation process. This work was funded by the NSF.

Citation: Wang J.; Albers†, T.; Grewer*, C. Energy Landscape of the Substrate Translocation Equilibrium of Plasma-Membrane Glutamate Transporters.  J. Phys. Chem. B, 2018, 122(1), 28–39

 


Lees Group

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An article by Arvind Kumar, Shih-Sheng Sun and Alistair J. Lees published in Photophysics of Organometallics has been ranked 221 out of 64157 articles (published between 2010 to 2014) by Web of Science.

Citation: Kumar A.; Sun S.S.; Lees A.J. Photophysics and Photochemistry of Organometallic Rhenium Diimine Complexes. In Photophysics of Organometallics, Lees A., Eds.; Topics in Organometallic Chemistry, Springer, Berlin, Heidelberg, 2009; vol 29.

Link: https://link.springer.com/book/10.1007%2F978-3-642-04729-9

 


Solmaz Group

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Dr. Sozanne Solmaz, Assistant Professor, has published a paper in the Journal Cell Cycle together with her students Kyle Loftus, Heying Cui, Amanda Ceravolo and Dylan Perreiras, as well as collaborators David King and Elias Coutavas from UC Berkeley and the Rockefeller University. The paper provides new insights how the transport of the nucleus within the cell is initiated in G2 phase. Transport of the nucleus is important for a fundamental process in brain development and faithful chromosome segregation. Defects in these transport processes cause cancer and microcephaly, a devastating brain developmental disease in infants. Results will help devise therapies for these devastating diseases.

Citation: Loftus, K.M.; Cui, H.; Coutavas, E.; King, D.S.; Ceravolo, A.; Pereiras, D.; Solmaz, S.R. Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. Cell Cycle, 2017, 16, 1414-1429.

Link: http://www.tandfonline.com/doi/full/10.1080/15384101.2017.1338218

 


Rozners Group

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A recent paper in Nucleic Acids Research “Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs” showcases results obtained by former graduate students Daniel Mutisya and Samwel Cheruiyot in collaboration with several academic and industrial research groups

Citation: Mutisya, D.; Hardcastle, D.; Cheruiyot, S.; Pallan, P.; Kennedy, S.; Egli, M.; Kelley, M.L.; van Brabant Smith, A.; Rozners, E. Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. Nucleic Acids Research, 2017, 14, 8142-8155.

Link: https://academic.oup.com/nar/article/45/14/8142/3894172

 


Rozners Group

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A recent paper in RNA journal "Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids” showcases results obtained by graduate student Dziyana Hnedzko and undergraduate research assistant Yannis Karamitas in collaboration with Professor Dennis McGee at the Biology Department.

Citation: Hnedzko, D.; McGee, D.W.; Karamitas, Y.A.; Rozners, E. Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids. RNA, 2017, 23:, 58-69 .

Link:  http://rnajournal.cshlp.org/content/23/1/58.abstract?etoc

 


Last Updated: 10/1/18