Kanneboyina Nagaraju received his bachelor's degree in veterinary medicine from the College of Veterinary Sciences, Tirupati, India, in 1986; his master's degree in veterinary immunology from the prestigious Indian Veterinary Research Institute, Izatnagar, in 1989; and his PhD in immunology from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India in 1995. Immediately after completing his PhD, he came to the United States to do a postdoctoral fellowship at the National Institutes of Health (NIH) in Bethesda, Md.
After completing this fellowship in 1999, he became a tenure-track assistant professor in the Division of Rheumatology, Department of Medicine of the Johns Hopkins University School of Medicine in Baltimore, Md. In 2005, he joined the Research Center of Genetic Medicine, Children's Research Institute of the Children's National Medical Center (CNMC) and was appointed an associate professor of pediatrics at the George Washington University School of Medicine and Health Sciences (GWSMHS) in Washington, D.C. In 2012, he was promoted to full professor with tenure in the Department of Integrative Systems Biology, GWSMHS, and in 2015 served as the interim chair of the Department of Integrative Systems Biology and director of the Research Center of Genetic Medicine at CNMC prior to moving to Binghamton.
Nagaraju is an expert on translational research in autoimmune and genetic muscle diseases. He has authored more than 120-refereed publications, along with several textbook chapters on autoimmune muscle diseases. Apart from identifying pathogenic pathways and drug targets in these neuromuscular disorders, he has also pioneered the generation of novel inducible transgenic and knockout mouse models for muscle and neuromuscular diseases. Early drug screening efforts in his laboratory in collaboration with Eric Hoffman and John McCall led to the identification of powerful anti-inflammatory, membrane stabilizing dissociated glucocorticoids. His group has demonstrated that these dissociated steroids are highly efficacious in several inflammatory disease models. The lead compound, vamorolone is currently in clinical trials for Duchenne muscular dystrophy.
Nagaraju has led international efforts to define reliable and sensitive tests for drug efficacy in mouse models of neuromuscular diseases and directed a state-of-the art preclinical drug-testing facility dedicated to neuromuscular disorders, and he has performed over 75 preclinical drug trials in these mouse models since 2006. In addition, he has mentored 20 postdoctoral and 7 doctoral fellows and students.
Since 2005, Nagaraju has received more than $11 million in grant support under various mechanisms (R01, R21, U54, P50, K26) from the National Institutes of Health, the U.S. Department of Defense and from a number of foundations (e.g., MDA, AFM, TMA, PPMD, Arthritis Foundation). He currently serves as a member of medical and scientific advisory boards of the Myositis Association, Muscular Dystrophy Association and Cure Duchenne, as well as on the editorial boards of several specialty journals. Additionally, he is one of the founding core preclinical experts on the TREAT-NMD Advisory Committee for Therapeutics.
Nagaraju has co-founded two biotech companies, ReveraGen BioPharma, a biotech company focused on developing dissociated glucocorticoid therapies for inflammatory diseases including muscular dystrophy, and AGADA BioSciences, a preclinical drug screening and phenotyping company to facilitate development of therapeutics for rare neuromuscular diseases.
- BVSc, College of Veterinary Sciences
- MVSc, Indian Veterinary Research Institute
- PhD, Sanjay Gandhi Postgraduate Institute of Medical Sciences
- Neuromuscular diseases
- Autoimmune diseases
- Drug development