Ryan Pelis received a BSc and MSc from the University of Massachusetts, Amherst, and a PhD in physiology and neurobiology from the University of Connecticut, Storrs. His postdoctoral training was in the Department of Physiology at the University of Arizona. From 2009-2012, he was a senior investigator and laboratory head in the Drug-Drug Interactions Section in the Department of Drug Metabolism and Pharmacokinetics at the Novartis Institutes for Biomedical Research in East Hanover, N.J. At Novartis, he managed an in vitro drug metabolism and drug transport laboratory whose research supported investigational new drug applications and new drug applications. From 2012-2018, Pelis was an assistant and then a tenured associate professor in the Department of Pharmacology in the Faculty of Medicine at Dalhousie University in Halifax, Nova Scotia, Canada. He joined the School of Pharmacy and Pharmaceutical Sciences at Binghamton University in 2018.
Pelis is interested in the role drug metabolizing enzymes and drug transporters play in pharmacokinetics. His primary research focus is on using in vitro data and physiologically-based pharmacokinetic (PBPK) modeling to predict drug absorption, distribution, metabolism and elimination following administration. These research efforts are helping move toward predicting interindividual variability in drug exposure and response due to factors such as disease, genetics and drug-drug interactions – information that is essential for the clinical registration of investigational drugs with the major pharmaceutical regulatory agencies (FDA and EMA). With this information, we will help develop safer and more cost-effective pharmaceutical therapies for individualized medicine.
- BS, University of Massachusetts
- MS, University of Massachusetts
- PhD, University of Connecticut
- Drug transport
- Drug metabolism
- Physiologically-based pharmacokinetic modeling