David G. Davies, PhD in Microbiology
Director, Binghamton Center for Biofilm Research
Associate Professor, Department of Biological Sciences
Research interests: My research lab is involved in the study of the biology of biofilm bacteria and how they regulate their behavior. My primary concern is how to control and manage biofilm growth in industrial, medical and household environments. Our approach to solving biofilm problems is to use physiological and molecular biological approaches to examine control points in biofilm development and cell-to-cell interactions within and between species.
Biofilm focus: Our laboratory is involved in research in four distinct areas relating to biofilms. These are: Biology of Biofilm Dispersion, Biofilm Virulence and Pathogenesis, Human Biofilm Infections and Development of Biofilm Control Methods. We have been investigating biofilm dispersion for several years and have identified and partially characterized the biofilm dispersion autoinduction pathway in Pseudomonas aeruginosa. We are continuing this work by investigating the signal transduction mechanism which controls biofilm dispersion autoinduction in P. aeruginosa and the regulatory process that drives the dispersion event. We are also investigating how dispersion affects a change in virulence in P. aeruginosa and other bacteria and how this impacts pathogenicity in several infection models, including A. thaliana, C. elegans, and L. sativa. In the area of human infections, we have been studying biofilms associated with arterial plaque deposits and are interested in how these bacteria influence patient health. In the area of Biofilm control, we are working on developing the dispersion inducer, cis-2-decenoic acid (cis-DA) into a commercially viable option to combat biofilm growth in a wide range of environments, from non-healing wounds to contact lenses to cooling towers.