Highlighted Publications

Catalysis Journal- Dimitrov Group

Dimitrov Group

The Dimitrov group reported on the development and application of all-electrochemically synthesized nanoporous (np) Au-Cu-Pt alloy thin film as catalysts for formic acid oxidation (FAO) reaction. The work emphasizes a pursuit of most efficient catalytic routes for the production of clean energy like by smart materials design at atomic level, involving controlled alloy electrodeposition followed by oxidative copper removal. The unique advantage of the best performing np Au-Cu-(2.6%)Pt catalyst is associated with its exclusive selectivity in support of the preferred direct FAO mechanism along with unseen long-lasting no-passivation behavior in the course of wide-potential-range cycling tests. 

Ultralow Pt-loading Nanoporous Au-Cu-Pt Thin Film as Highly Active and Durable Catalyst for Formic Acid Oxidation, Yunxiang Xie and Nikolay Dimitrov, Applied Catalysis B: Environmental, 2019, October 31 (https://doi.org/10.1016/j.apcatb.2019.118366) [Epub ahead of print].

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PNAS- Qiang Group

Qiang Group

A collaborative work from the Qiang group and the Vugmeyster group at CU Denver has been published on PNAS. This work solved the very first molecular structure of a post-translational modified beta-amyloid fibril. This site-specific modification, with the phosphorylation at residue S8 on Abeta sequence, induces the formation of a more-ordered N-terminal fibril structure with more thermodynamic stable core. In addition, this modification leads to rapid cross-seeded fibrillation to the wild-type Abeta, which may accelerate the pathological amyloid deposition.

This work has been posted as a University Research News headline on the Office of Science homepage at https://www.energy.gov/science/office-science , and reported in the PNAS news

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ACS- Pantier Group

Pantier Group

The Panetier group, in collaboration with the Jurss group at the University of Mississippi, reported a joint experimental and computational study on the use of three novel cobalt catalysts for electrochemical CO2 reduction in aqueous solutions. This study shows that as the rigidity of the macrocycle is increased, selectivity and activity for CO2 reduction over the competing hydrogen evolution reaction is enhanced. As such the most rigid catalyst performs CO2 reduction in water with an overpotential of 420 mV and a Faradaic yield of 93%.

X. Su, K.M. McCardle, L. Chen, J.A. Panetier and J.W. Jurss, Robust and Selective Cobalt Catalysts Bearing Redox-Active Bipyridyl-N-heterocyclic Carbene Frameworks for Electrochemical CO2 Reduction in Aqueous Solutions, ACS Catal. 2019, 9, 7398−7408Chem Biol. 2019 May 6. doi: 10.1021/acschembio.9b00194 [Epub ahead
of print].

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ACS- Grewer GroupGrewer Group

Laura Zielewicz from the Grewer laboratory published her research on the mechanism of inhibition of glutamate transporters in ACS Chemical Biology. This work shows that binding of negatively-charged inhibitors occurs within the transmembrane electric field, resulting in voltage dependence of inhibitor binding and dissociation. This finding is important for our understanding of how glutamate interacts with the transporter at the excitatory synapse in the mammalian brain.

Transient Kinetics Reveal Mechanism and Voltage Dependence of Inhibitor and Substrate Binding to Glutamate Transporters. Zielewicz L, Wang J, Ndaru E, Grewer CT ACS Chem Biol. 2019 May 6. doi: 10.1021/acschembio.9b00194 [Epub ahead of print].

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JACS- Pantier Group

Pantier Group

The Panetier group, in collaboration with researchers from Texas A&M University and DePaul University, reported a joint experimental and computational study on the use of imidazolium-functionalized manganese tricarbonyl bipyridine complexes for CO2reduction. This study, which was published in JACS, suggests that imidazolium groups in the secondary coordination sphere promote the formation of a local hydration shell that facilitates the protonation of CO2 reduction intermediates.

S. Sung, X. Li, L.M. Wolf, J.R. Meeder, N.S. Bhuvanesh, K.A. Grice, J.A. Panetier, and M. Nippe, Synergistic Effects of Imidazolium-Functionalization on fac-Mn(CO)3 Bipyridine Catalyst Platforms for Electrocatalytic Carbon Dioxide Reduction, J. Am. Chem. Soc. 2019, 141, 6569-6582.

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Chemistry European- Rozners Group Rozners Group

In collaboration with colleagues from University of Rochester and Elizabethtown College, Rozners group has published a paper “Synthetic, Structural, and RNA Binding Studies on 2-Aminopyridine-Modified Triplex-Forming Peptide Nucleic Acids” in Chemistry: A European Journal. The study was designated as Very Important Paper by the reviewers and featured as a Cover Picture of the March 21 issue of Chemistry: A European Journal.

Kotikam, V., Kennedy, S. D., MacKay, J. A., and Rozners, E. Synthetic, Structural, and RNA Binding Studies on 2-Aminopyridine-Modified Triplex-Forming Peptide Nucleic Acids. Chem. Eur. J. 2019, 25,4367- 4372.

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JGP- Grewer Group

Grewer Group

Elias Ndaru published work on the synthesis and characterization of novel inhibitors of alanine cysteine serine transporter ASCT2, in collaboration with the laboratory of Dr. Avner Schlessinger from Mount Sinai School of Medicine. Amino acid derivatives with sulfonic acid ester and sulfonamide linkages were identified as ASCT2 inhibitors with the most potent compound displaying an affinity in the low microM range.

Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds. Ndaru E, Garibsingh RA, Shi Y, Wallace E, Zakrepine P, Wang J, Schlessinger A, Grewer C. J Gen Physiol., 2019 Feb 4 epub ahead of print.

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PNAS- Qiang and An Groups

Qiang & An Groups

A collaborative work from the Qiang and An groups has recently been published on PNAS. This work describes the studies of thermodynamic intermediate states of interactions between pH-Low insertion (pHLIP) peptides and membrane bilayers, using advanced solid-state NMR spectroscopy. A multi-stage pH-modulated membrane insertion model for pHLIP peptides was proposed. Graduate and undergraduate students S. Otieno, S. Hanz, B. Chakravorty from the Qiang group, and graduate students A. Zhang and L. Klees from the An group contributed to this work.

S.A. Otieno, S.Z. Hanz, B. Chakravorty, A. Zhang, L.M. Klees, M. An, and W. Qiang, pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy. Proc. Natl. Acad. Sci. U.S.A., 2018, 115(48), 12194-12199.

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JACS- Fang Group

Fang Group

The Fang group, in collaboration with researchers from Cornell and NTU, recently reported their observation of phase transitions of formamidinium lead iodide (FAPbI3) under pressure. The article was just accepted by J. Am. Chem. Soc. FAPbI3 is a hybrid compound, consisting of a perovskite alpha-phase and hexagonal (non-perovskite) delta-phase. Study on the pressure-induced structural evolution of this organic-inorganic compound is a hot topic. For the first time, the authors determined that the pressure could accelerate the alpha- to delta-FAPbI3 transformation.

Shaojie Jiang, Yiliang Luan, Joon I. Jang, Tom Baikie, Xin Huang, Ruipeng Li, Felix O. Saouma, Zhongwu Wang, Timothy J. White and Jiye Fang, Phase Transitions of Formamidinium Lead Iodide Perovskite under Pressure, J. Am. Chem. Soc., 2018, 140(42), 13952-13957.

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Chemistry European- Vetticat Group

Vetticat Group

The honor thesis research of an undergraduate student Vladislav Roytman is the subject of a recent publication in Chem. Eur. J. from the Vetticatt group at Binghamton University. This paper details the use of 13C kinetic isotope effects and DFT calculations as a novel probe to distinguish between of enol and enamine mechanisms in aminocatalysis.

Roytman, V. A.; Karugu, R. W.; Hong, Y.; Hirschi, J. S.; Vetticatt, M. J. 13C Kinetic Isotope Effects as a Quantitative Probe To Distinguish between Enol and Enamine Mechanisms in Aminocatalysis Chem. Eur. J. 2018, 24(32), 8098-8102.

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