Our Faculty

headshot of Sha Jin

Sha Jin

Professor/Undergraduate Director

Biomedical Engineering

Background

Research Focus

Stem cells for tissue engineering and regenerative medicine, bioinformatics, proteomics, bioimaging, molecular genetics and cell biology, environmental science and food science.

The lab focuses on fundamental and transformative studies of stem cell differentiation and interplay between cells and their microenvironments with an ultimate goal of generating clinically relevant tissues/organoids for disease modeling, drug discovery and cell-based therapy. One of the major focuses of the lab is to engineer tissue microenvironments to produce biologically functional organoids and to promote the maturation of stem cells-derived tissues/organoids. In addition, the lab interrogates the molecular mechanisms underlying the synergistic regulation of physiochemical signals by tissue cues to which cells are exposed in vivo, leading to the development of bioinspired materials and substrates for directing cell proliferation, differentiation and assembly into a functional tissue or organ in vitro.

Another research focus of the lab is to mitigate global warming and climate change caused by environmental pollution. We aim to apply modern biotechnology and bioengineering approaches to convert food waste into ecofriendly industrial/medical products.

Tissue Biomolecular Lab

Complete List of Publications

Selected Recent Publications

Complete List of Publications: scholar.google.com/citations?user=9opTdwUAAAAJ&hl=en

Heaton, E. and Jin, S. “Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment”. Translational Research. (Invited review) July 21, 2022 DOI:https://doi.org/10.1016/j.trsl...

Freeman, S., Calabro, S., Williams, R., Jin, S., and Ye, K. “Bioink Formulation and Machine Learning-Empowered Bioprinting Optimization”. Front. Bioeng. Biotechnol., 13 June 2022, https://doi.org/10.3389/fbioe.....

Moffat, D., Ye, K., and Jin, S., “Decellularization for the Retention of Tissue Niches”. Journal of Tissue Engineering. 13: 1–29; May 21, 2022. https://doi.org/10.1177/204173...

    Freeman, S., Kibrler, K., Lipsky, Z., Jin, S., German, G., and Ye, K. “Systematic Evaluating and Modeling of SARS-CoV-2 UVC Disinfection”. Sci Rep. 12, 5869 (2022). https://doi.org/10.1038/s41598....

    Yefroyev, D.A., and Jin, S. (2022) “Induced Pluripotent Stem Cells for Treatment of Alzheimer’s and Parkinson’s Diseases”. Biomedicines. 10(2), 208; https://doi.org/10.3390/biomedicines10020208.

    Hu, M., Bi, H., Moffat, D., Blystone, M., DeCostanza, P., Alayi, T., Ye, K., Hathout, Y., and Jin, S. (2021) “Proteomic and Bioinformatic Analysis of Decellularized Pancreatic Extracellular Matrices”. Molecules. 26(21), 6740; https://doi.org/10.3390/molecules26216740

    Karanth, SK., Sun, S., Bi, H., Ye, K., and Jin, S. (2021) “Angiopoietins stimulate pancreatic islet development from stem cells.” Sci Rep. 2021, Jun 30;11(1):13558. https://doi.org/10.1038/s41598-021-92922-5

    Huang H., Bader, T., and Jin, S. (2020) “Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation.” Int J Mol Sci. 2020, 21(16), 5867; https://doi.org/10.3390/ijms21165867

    Bi, H., Karanth, S., Ye, K., Stein, R., and Jin, S. (2020) “Decellularized Tissue Matrix Enhances Self-Assembly of Islet Organoids from Pluripotent Stem Cell Differentiation.” ACS Biomaterials Science & Engineering. May 21, 2020, https://pubs.acs.org/doi/full/10.1021/acsbiomaterials.0c00088

    Bi, H., Ye, K., and Jin, S. (2020) “Proteomic analysis of decellularized pancreatic matrix identifies collagen V as a critical regulator for islet organogenesis from human pluripotent stem cells.” Biomaterials. 233: 119673.

    Jayaraman, S., Bi, H., Sen, P., Everhart, B., Jin, S., and Ye, K. “Inducing Tumor Suppressive Microenvironments through Genome Edited CD47−/− Syngeneic Cell Vaccination.” Sci Rep 9, 20057 (2019) doi:10.1038/s41598-019-56370-6

    Freeman, S., Ramos, R., Chando, PA., Zhou, L., Reeser, K., Jin, S., Soman, P., and Ye, K. (2019) “A bioink blend for rotary 3D bioprinting tissue engineered small-diameter vascular constructs.” Acta Biomaterialia, 95, 152-164.

    Hai, N., Shin, D.W., Bi, H., Ye, K., and Jin, S. (2018)Mechanistic analysis of physicochemical cues in promoting human pluripotent stem cell self-renewal and metabolism.” Int J Mol Sci. 2018 Nov 4;19(11), doi:10.3390/ijms19113459

    Xia, Z., Jin,S., and Ye,K. (2018) Tissue and Organ 3D Bioprinting, SLAS Technol. Feb 1:2472630318760515. doi: 10.1177/2472630318760515.

    Wang W., Jin,S., and Ye,K. (2017) Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds. Stem Cells Dev. 2017 Jan 11. doi: 10.1089/scd.2016.0115.

    Lei, H., Jin, S., Karlsson, E., Schultz-Cherry, S., and Ye, K. (2016). Yeast Surface Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research 2016: 4131324. doi: 10.1155/2016/4131324.

    McReynolds, J., Wen, Y., Li, X., Guan, J., and Jin, S. (2016) Modeling Spatial Distribution of Oxygen in 3D Culture of Islet beta-Cells. Biotechnology Progress. 2016 Nov 1. doi: 10.1002/btpr.2395.

    Zhou C., Jin, S., and Willing, R. (2016) Simulation of extracellular matrix remodeling by fibroblast cells in soft three-dimensional bioresorbable scaffolds. Biomech Model Mechanobiol. 15(6):1685-1698

    Leach, J.C.; Wang, A.; Ye, K.; Jin, S. (2016) A RNA-DNA Hybrid Aptamer for Nanoparticle-Based Prostate Tumor Targeted Drug Delivery. Int. J. Mol. Sci.17(3) 380. doi: 10.3390/ijms17030380

    Wang, L., Wang, R., Kong, BW., Jin, S., Ye, K., Fang, W. and Li, Y. (2015) B cells using a calcium signaling for specific and rapid detection of Escherichia coli O157:H7. Scientific Reports Jun 2; 5:10598. doi: 10.1038/srep10598

    Enam, S. and Jin, S. (2015) Substrates for clinical applicability of stem cells. World J. Stem Cells. 7(2): 243-252

    Wen, Y. and Jin, S. (2014) Production of neural stem cells from human pluripotent stem cells. J. Biotechnology 188C:122-129

    Jin, S. (2014) Regeneration of Islet β-cells from stem cells and progenitors. J. Stem Cell Research & Transplantation 1(1):4

    Alismail, H. and Jin, S. (2014) Microenvironmental stimuli for proliferation of functional islet β-cells. Cell & Bioscience 4:12

    Zaki, S. and Jin, S. (2014) Targeted therapies against gliomas. J. of Tumor 2(3): 99-107

    Jin, S. (2013) Therapeutic potential of natural catechins in antiviral activity. JSM Biotechnology & Biomedical Engineering 1: 1002

    Jin, S., and Ye, K. (2013) Targeted drug delivery for breast cancer treatment. Recent patents on anti-cancer drug discovery, 8(2):143-153.

    Earls, J., Jin, S., and Ye, K. (2013) Mechanobiology of human pluripotent stem cells. Tissue Engineering, Part B. April 16.

    Yao, H., Jin, S. (2012) Enhancement of probe signal for screening of HIV-1 protease inhibitors in living cells. Sensors 12 (12): 16759-16770.

    Jin, S., Yao, H., Weber, J.L., Melkoumian, Z.K., and Ye, K. (2012) A synthetic, xeno-free peptide surface for expansion and directed differentiation of human induced pluripotent stem cells. PLoS ONE. 7(11): e50880. doi:10.1371/journal.pone.0050880

    Jin, S., Yao, H., Krisanarungson, P., Haukas, A. and Ye, K. (2012) Porous membrane substrates offer better niches to enhance the Wnt signaling and promote human embryonic stem cell growth and differentiation, Tissue Engineering: Part A. 18(13-14): 1419-1430.

    Veetil, JV, Jin, S., Ye, K. (2012) Fluorescence lifetime imaging microscopy of intracellular glucose dynamics. Journal of Diabetes Science and Technology. 6(6):1276–1285.

    Ye, K. and Jin, S. (2011) Directed differentiation of human embryonic stem and patient-specific stem cells into lineage-specific cells for regenerative medicine, Humana Press, USA. ISBN 13: 9781617792663, ISBN 10: 1617792667.

    Zhu, Y., Dong, Z., Wejinya, U.C., Jin, S., and Ye, K. (2011) Determination of mechanical properties of soft tissue scaffolds by atomic force microscopy nanoindentation. J. Biomechanics. 44, 2356-2361.

    Jin, S, Veetil, JV, Garrett, JR., Ye, K. (2011) Construction of a panel of glucose indicator proteins for continuous glucose monitoring. Biosensors and Bioelectronics. 26, 3427-3431.

    Jin, S, Ellis, E., Veetil. JV, Yao, H. and Ye. K. (2011) Visualization of human immunodeficiency virus protease inhibition using a novel Förster resonance energy transfer molecular probe. Biotechnol. Prog. 27 (4), 1107-1114.

    Veetil, V.J., Jin, S. and Ye, K. (2010) A Glucose Sensor Protein for Continuous Glucose Monitoring. Biosensors and Bioelectronics. 26, 1650–1655.

    Zhang, B., Sun, C., Jin, S., Cascio, M., and Montelaro, R.C. (2008) Mapping of equine lentivirus receptor 1 residues critical for EIAV envelope binding. J. Virol. 82: 1204-1213.

    Garett, J.R., Wu, X., Sha, J. and Ye, K. (2008) pH-insensitive Glucose Indicators. Biotechnol. Prog. 24, 1085-1089

    Jin, S., Ye, K., (2007) Nanoparticles-mediated drug delivery and gene therapy. Biotechnol. Progress. 23: 32-41.

    Ye, K., Jin, S., (2006) Potent and Specific Inhibition of Retroviral Replication by Coexpression of Multiple siRNAs Directed Against Different Regions of Viral Genomes. Biotechnol. Progress. 22: 45-52.

    Jin, S., Weisz, O., and Montelaro, R. C. (2005) pH-dependent endocytic entry by equine infectious anemia virus infection. J. Virol. 79(23):14489-97.

    Zhang, B., Jin, S., Jin, J., Li, F., and Montelaro, R. C. (2005) A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus. Proc Natl Acad Sci U S A 102(28): 9918-9923.

    Jin, S., Chen, C., and Montelaro, R. C. (2005) Equine infectious anemia virus Gag p9 function in early steps of virus infection and provirus production. J. Virol. 79(14): 8793-8801.

    Education

    • BS, MS, East China University of Science and Technology
    • PhD, Kyushu University Institute of Technology

    Research Interests

    • Stem cells and tissue engineering
    • Proteomics and bioinformatics
    • Signaling transduction and signaling pathways
    • Bioprocess for producing ecofriendly industrial/medical products
    • Environmental protection

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