Stem cell for tissue engineering and regenerative medicine, mechanobiology, molecular genetics and cell biology, nanosensor development, vaccine development.
The Lab focuses on fundamental study of stem cell differentiation and interplay between cells and their microenvironments with an ultimate goal of generating cell-based therapeutics for cell-based therapy; development of chemically defined xeno-free culture system for human pluripotent stem cell self-renewal and lineage specification; niches for biologically functional cell; interrogation of the molecular mechanisms underlying the synergistic regulation of physiochemical signals by tissues cues to which cells are exposed in vivo, leading to the development of bioinspired materials and substrates for directing cell proliferation, differentiation, migration, and assembly into a functional tissue or organ in vitro. Other major focuses of the lab are the development of multiplexed drug delivery systems for cancer treatment through biotechnology and bioengineering approaches, development of nanosensors for disease diagnosis and treatment, and vaccine development for anti-viral infection.
Selected Recent Publications
Wang W., Jin,S., and Ye,K. (2017) Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds. Stem Cells Dev. 2017 Jan 11. doi: 10.1089/scd.2016.0115.
Lei, H., Jin, S., Karlsson, E., Schultz-Cherry, S., and Ye, K. (2016). Yeast Surface Displayed H5N1 Avian Influenza Vaccines. Journal of Immunology Research 2016: 4131324. doi: 10.1155/2016/4131324.
McReynolds, J., Wen, Y., Li, X., Guan, J., and Jin, S. (2016) Modeling Spatial Distribution of Oxygen in 3D Culture of Islet beta-Cells. Biotechnology Progress. 2016 Nov 1. doi: 10.1002/btpr.2395.
Zhou C., Jin, S., and Willing, R. (2016) Simulation of extracellular matrix remodeling by fibroblast cells in soft three-dimensional bioresorbable scaffolds. Biomech Model Mechanobiol. 15(6):1685-1698
Leach, J.C.; Wang, A.; Ye, K.; Jin, S. (2016) A RNA-DNA Hybrid Aptamer for Nanoparticle-Based Prostate Tumor Targeted Drug Delivery. Int. J. Mol. Sci.17(3) 380. doi: 10.3390/ijms17030380
Wang, L., Wang, R., Kong, BW., Jin, S., Ye, K., Fang, W. and Li, Y. (2015) B cells using a calcium signaling for specific and rapid detection of Escherichia coli O157:H7. Scientific Reports Jun 2; 5:10598. doi: 10.1038/srep10598
Enam, S. and Jin, S. (2015) Substrates for clinical applicability of stem cells. World J. Stem Cells. 7(2): 243-252
Wen, Y. and Jin, S. (2014) Production of neural stem cells from human pluripotent stem cells. J. Biotechnology 188C:122-129
Jin, S. (2014) Regeneration of Islet β-cells from stem cells and progenitors. J. Stem Cell Research & Transplantation 1(1):4
Alismail, H. and Jin, S. (2014) Microenvironmental stimuli for proliferation of functional islet β-cells. Cell & Bioscience 4:12
Zaki, S. and Jin, S. (2014) Targeted therapies against gliomas. J. of Tumor 2(3): 99-107
Jin, S. (2013) Therapeutic potential of natural catechins in antiviral activity. JSM Biotechnology & Biomedical Engineering 1: 1002
Jin, S., and Ye, K. (2013) Targeted drug delivery for breast cancer treatment. Recent patents on anti-cancer drug discovery, 8(2):143-153.
Earls, J., Jin, S., and Ye, K. (2013) Mechanobiology of human pluripotent stem cells. Tissue Engineering, Part B. April 16.
Yao, H., Jin, S. (2012) Enhancement of probe signal for screening of HIV-1 protease inhibitors in living cells. Sensors 12 (12): 16759-16770.
Jin, S., Yao, H., Weber, J.L., Melkoumian, Z.K., and Ye, K. (2012) A synthetic, xeno-free peptide surface for expansion and directed differentiation of human induced pluripotent stem cells. PLoS ONE. 7(11): e50880. doi:10.1371/journal.pone.0050880
Jin, S., Yao, H., Krisanarungson, P., Haukas, A. and Ye, K. (2012) Porous membrane substrates offer better niches to enhance the Wnt signaling and promote human embryonic stem cell growth and differentiation, Tissue Engineering: Part A. 18(13-14): 1419-1430.
Veetil, JV, Jin, S., Ye, K. (2012) Fluorescence lifetime imaging microscopy of intracellular glucose dynamics. Journal of Diabetes Science and Technology. 6(6):1276–1285.
Ye, K. and Jin, S. (2011) Directed differentiation of human embryonic stem and patient-specific stem cells into lineage-specific cells for regenerative medicine, Humana Press, USA. ISBN 13: 9781617792663, ISBN 10: 1617792667.
Zhu, Y., Dong, Z., Wejinya, U.C., Jin, S., and Ye, K. (2011) Determination of mechanical properties of soft tissue scaffolds by atomic force microscopy nanoindentation. J. Biomechanics. 44, 2356-2361.
Jin, S, Veetil, JV, Garrett, JR., Ye, K. (2011) Construction of a panel of glucose indicator proteins for continuous glucose monitoring. Biosensors and Bioelectronics. 26, 3427-3431.
Jin, S, Ellis, E., Veetil. JV, Yao, H. and Ye. K. (2011) Visualization of human immunodeficiency virus protease inhibition using a novel Förster resonance energy transfer molecular probe. Biotechnol. Prog. 27 (4), 1107-1114.
Veetil, V.J., Jin, S. and Ye, K. (2010) A Glucose Sensor Protein for Continuous Glucose Monitoring. Biosensors and Bioelectronics. 26, 1650–1655.
Zhang, B., Sun, C., Jin, S., Cascio, M., and Montelaro, R.C. (2008) Mapping of equine lentivirus receptor 1 residues critical for EIAV envelope binding. J. Virol. 82: 1204-1213.
Garett, J.R., Wu, X., Sha, J. and Ye, K. (2008) pH-insensitive Glucose Indicators. Biotechnol. Prog. 24, 1085-1089
Jin, S., Ye, K., (2007) Nanoparticles-mediated drug delivery and gene therapy. Biotechnol. Progress. 23: 32-41.
Ye, K., Jin, S., (2006) Potent and Specific Inhibition of Retroviral Replication by Coexpression of Multiple siRNAs Directed Against Different Regions of Viral Genomes. Biotechnol. Progress. 22: 45-52.
Jin, S., Weisz, O., and Montelaro, R. C. (2005) pH-dependent endocytic entry by equine infectious anemia virus infection. J. Virol. 79(23):14489-97.
Zhang, B., Jin, S., Jin, J., Li, F., and Montelaro, R. C. (2005) A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus. Proc Natl Acad Sci U S A 102(28): 9918-9923.
Jin, S., Chen, C., and Montelaro, R. C. (2005) Equine infectious anemia virus Gag p9 function in early steps of virus infection and provirus production. J. Virol. 79(14): 8793-8801.
- BS, MS, East China University of Science and Technology
- PhD, Kyushu University Institute of Technology
- Stem cells and tissue engineering
- biomolecular engineering