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Gano, A., Vore, A.S., Sammakia, M.N. & Deak, T. (2019). Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large-molecule microdialysis combined with multiplex arrays after cute and chronic ethanol exposure. Alcoholism: Clinical and Experimental Research, 43(4): 640-54. PMID: 30667526 PMCID: 6443416 doi: 10.1111/acer.13963

Gano, A., Mondello, J.E., Doremus-Fitzwater, T.L. & Deak, T. (2019). Rapid alterations in neuroimmune gene expression after acute ethanol: timecourse, sex differences, and sensitivity to cranial surgery.  Journal of Neuroimmunology, 337: 577083. PMID: 31675629 PMCID: PMC6866658 doi: 10.1016/j.neuroim.2019.577083

Gano, A., Pautassi, R.M., Doremus-Fitzwater, T.L., Barney, T.M., Vore, A.S. & Deak, T. (2019). Conditioning the neuroimmune response to ethanol using taste and environmental cues in adolescent and adult rats.  Experimental Biology & Medicine, 244(5): 362-71. PMID: 30808184 PMCID: PMC6488863 doi: 10.1177/1535370219831709

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Perkins, A.E., Varlinskaya, E.I. & Deak, T. (2019). From adolescence to late aging: a comprehensive review of social behavior, alcohol and neuroinflammation across the lifespan.  International Review of Neurobiology, 148: 231-303.  PMID: 31733665 PMCID: PMC7265136 doi: 10.1016/bs.irn.2019.08.001

Saalfield, J. & Spear, L.P. (2019). Fos activation patterns related to acute ethanol and conditioned taste aversion in adolescent and adult rats. Alcohol, 78: 57-69. PMID: 30797833 PMCID: PMC6612301 doi: 10.1016/j.alcohol.2019.02.004

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Toledo-Nunes, P., Vedder, L.C., Deak, T. & Savage, L.M. (2019). A privotal role for thiamine deficiency in the expression of neuroinflammmation markers in models of alcohol-related brain damage. Alcoholism: Clinical and Experimental Research, 43(3): 425-38. PMID: 30589435 PMCID: PM6397077 doi: 10.1111/acer.13946

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Ignacio C, Mooney SM, Middleton FA (2014). Effects of acute prenatal exposure to ethanol on microRNA expression are ameliorated by social enrichment. Frontiers in Pediatrics, 2:13. doi: 10.3389/fped.2014.00103. PMCID: PMC 4173670 (PDF)

Mantella NM, Youngentob SL (2014). Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. PLoS One, 9(7):e10225. doi: 10.1371/journal.pone.0102255. PMCID: PMC41000884 PDF)

Anderson RI & Spear LP (2014). Age differences in ethanol discrimination: acquisition and ethanol dose generalization curves following multiple training conditions in adolescent and adult rats. Alcohol Clin Exp Res, 38(1): 186-94. (

Fabio MC, Nizhnikov ME, Spear NE & Pautassi RM (2014). Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. Dev Psychobiol, 56(3): 574-83. (

Morales M, Schatz KC, Anderson RI, Spear LP & Varlinskaya EI (2014). Conditioned taste aversion to ethanol in a social context: Impact of age and sex. Behav Brain Res, 261: 323-27. (

Nizhnikov ME, Pautassi RM, Carter JM, Landin JD, Varlinskaya EI, Bordner KA, Werner DF & Spear NE (2014). Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62, 066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression. Alcohol Clin Exp Res, 38(6): 1630-38. (

Miranda-Morales RS, Nizhnikov ME & Spear NE (2014). Prenatal exposure to ethanol during late gestation facilitates operant self-administration of the drug in 5-day-old rats. Alcohol, 48(1): 25-33. (

Spear LP (2013). Adolescents and alcohol: Acute sensitivities, enhanced intake, and later consequences. Neurotoxicol, Teratol, 41: 51-59. (

Fabio MC, March SM, Molina JC, Nizhnikov ME, Spear NE & Pautassi RM (2013). Prenatal ethanol exposure increases ethanol intake and reduces C-fos expression in infralimbic cortex of adolescent rats. Pharmacol Biochem Behav, 103(4): 842-52. (

Morales M, Varlinskaya EI & Spear LP (2013). Anxiolytic effects of the GABAa receptor partial agonist, L-838,417: Impact of age, test context familiarity, and stress. Pharmacol Biochem Behav, 109: 31-37. (


Acevedo MB, Nizhnikov M, Spear NE, Molina JC & Pautassi RM (2013). Ethanol-induced locomotor activity in adolescent rats and relationships with ethanol-induced conditioned place preference and conditioned taste aversion. Dev Psychobiol, 55(4): 429-42. (

Anderson RI, Morales M, Spear LP & Varlinskaya EI (2013). Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl), 231(8): 1687-93. (

Morales M, Anderson RI, Spear LP & Varlinskaya EI (2013). Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. Dev Psychobiol, 56(4): 700-12. (

Kozlov AP, Nizhnikov ME, Kramskaya TA, Varlinskaya EI & Spear NE (2013). Mu-opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation. Pharmacol Biochem Behav, 103(4): 773-782. (

Morales M, Varlinskaya EI & Spear LP (2013). Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behav Brain Res, 250: 18-22. (

Nichols A., OÕDell R., Powrozek TA & Olson EC (2013). Ex utero electroporation and whole hemisphere explants: a simple method for studies of early cortical development. J Vis Exp, 3: 74. (

Morales M & Spear LP (2013). The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats. Psychopharmacology, (

Anderson RI, Bush PC & Spear LP (2013). Environmental manipulations alter age differences in attribution of incentive salience to reward-paired cues. Behav Brain Res, 257: 83-89. (


Acevedo MB, Nizhnikov ME, Spear NE, Molina JC & Pautassi RM (2012). Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion. Dev Psychobiol, 55(4): 429-42. (

Powrozek TA & Olson EC (2012). Ethanol-induced disruption of Golgi apparatus morphology, primary neurite number and cellular orientation in developing cortical neurons. Alcohol, 46: 619-27. (

Pautassi RM, Nizhnikov ME, Fabio MC & Spear NE (2012). Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity. Pharmacol Biochem Behav,100(3): 630-638. (

Anderson RI, Agoglia AE, Morales M, Varlinskaya EI & Spear LP (2012). Stress, kappa manipulations, and aversion effects of ethanol in adolescent and adult male rats. Neuroscience, 249: 214-22. (

Pautassi RM, Nizhnikov ME & Spear NE (2012). Ethanol-mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration. Dev Psychobiol, 54(1): 98-104. (

Pautassi RM, Nizhnikov ME, Spear NE & Molina JC (2012). Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement. Alcohol, 46(6): 585-593. (

Cameron DA, Middleton FA, Chenn A & Olson EC (2012). Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development. BMC Neurosci, 13(1): 90. (

Glendinning JI, Simons YM, Youngentob L & Youngentob SL (2012). Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats. Exp Biol Med (Maywood), 237(3): 236-240. (.pdf, 905kb)

Hicks SD, Lewis L, Ritchie J, Burke P, Abdul-Malak Y, Adackpara N, Canfield K, Shwarts E, Gentile K, Meszaros ZS & Middleton FA (2012). Evaluation of cell proliferation, apoptosis, and dna-repair genes as potential biomarkers for ethanol-induced cns alterations. BMC Neurosci, 13(1): 128. (.pdf, 1.9mb)

Kozlov AP, Nizhnikov ME, Varlinskaya EI, & Spear NE (2012). The role of social isolation in ethanol effects on the preweanling rat. Behav Brain Res, 227(1): 43-57. (.pdf, 2.6mb)

Meszaros ZS, Dimmock JA, Ploutz-Snyder R, Chauhan SV, Abdul-Malak Y, Middleton FA & Batki SL (2012). Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder. Schizophr Res, 132(2-3): 190-193. (.pdf, 303kb)

Middleton FA, Varlinskaya EI &Mooney SM (2012). Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment. Dev Neurosci, 34(2-3): 115-128. (

Middleton FA, Varlinskaya EI & Mooney SM (2012). Behavioral and molecular effects of acute prenatal exposure to ethanol are altered by social enrichment. Alcohol Clin Exp Res Supplement.

Miranda-Morales RS, Molina JC, Spear NE & Abate P (2012). Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm. Psychopharmacology (Berl) 219(1): 235-246. (

Pautassi RM, Nizhnikov ME, Acevedo MB & Spear NE (2012). Early role of the kappa opioid receptor in ethanol-induced reinforcement. Physiol Behav 105(5): 1231-1241. (

Nizhnikov ME, Pautassi RM, Varlinskaya EI, Rahmani P, & Spear NE (2012). Ontogenetic differences in ethanol's motivational properties during infancy. Alcohol, 46(3): 225-234. (

Powrozek TA & Olson EC (2012). Ethanol-induced disruption of Golgi apparatus morphology, primary neurite number and cellular orientation in developing cortical neurons. Alcohol, 46(7): 619-627, 2012. (

Varlinskaya EI, Vogt BA & Spear LP (2012). Social context induces two unique patterns of c-Fos expression in adolescent and adult rats.  Dev Psychobiol, 55(7): 684-97, 2012. (

Youngentob SL, Kent PF & Youngentob LM (2012). Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol. Exp Biol Med (Maywood), 237(10): 1197-1208. (.pdf, 558kb)


Arias C & Spear NE (2011). Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats. Pharmacol Biochem Behav, 100(1): 81-85. (.pdf, 643kb)

Mooney SM & Varlinskaya EI (2011). Acute prenatal exposure to ethanol and social Behav Brain Res, 216(1): 358-364. (.pdf, 610kb)

Pautassi RM, Myers M, Spear LP, Molina JC & Spear NE (2011). Ethanol induces second-order aversive conditioning in adolescent and adult rats. Alcohol, 45(1): 45-55. (.pdf, 422kb)

Pautassi RM, Nizhnikov ME, Acevedo MB & Spear NE (2011). Naloxone blocks ethanol-mediated appetitive conditioning and locomotor activation in adolescent rats. Behav Brain Res, 216(1): 262-269. (.pdf, 94kb)

Pautassi RM, Nizhnikov ME, Fabio MC & Spear NE (2011). An acetaldehyde-sequestering agent inhibits appetitive reinforcement and behavioral stimulation induced by ethanol in preweanling rats. Pharmacol Biochem Behav, 97(3): 462-469. (.pdf, 352kb)

Pautassi RM, Nizhnikov ME, Truxell E, Varlinskaya EI & Spear NE (2011). Ontogeny of ethanol intake in alcohol preferring (P) and alcohol nonpreferring (NP) rats. Dev Psychobiol, 53(3): 234-245. (.pdf, 1.2mb)

Ponce LF, Pautassi RM, Spear NE & Molina JC (2011). Maternal care alterations induced by repeated ethanol leads to heightened consumption of the drug and motor impairment during adolescence: a dose-response analysis. Physiol Behav, 103(5): 477-486. (

Pueta M, Rovasio RA, Abate P, Spear NE & Molina JC (2011). Prenatal and postnatal ethanol experiences modulate consumption of the drug in rat pups, without impairment in the granular cell layer of the main olfactory bulb.  Physiol Behav, 102(1): 63-75. (.pdf, 2.2mb)

Ramirez RL, Varlinskaya EI & Spear LP (2011). Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. Alcohol Clin Exp Res, 35(6): 1149-1159. (.pdf, 479kb)

Spear LP (2011). Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data. Dev Cogn Neurosci, 1(4): 392-400. (.pdf, 345kb)

Robinson DL, Zitzman DL, Smith KJ & Spear LP (2011). Fast dopamine release events in the nucleus accumbens of early adolescent rats. Neuroscience, 176:296-307. (.pdf, 230kb)

Pautassi RM, Myers M, Spear LP, Molina JC & Spear NE (2011). Ethanol induces second-order aversive conditioning in adolescent and adult rats. Alcohol, 45:45-55. (.pdf, 409kb)

Broadwater M, Varlinskaya EI & Spear LP (2011). Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcohol Clin Exp Res, 35:1392-1403. (.pdf, 1.4mb)


Varlinskaya EI, Doremus-Fitzwater TL & Spear LP (2010). Repeated restraint stress alters sensitivity to the social consequences of ethanol in adolescent and adult rats. Pharmacol Biochem Behav, 96:228-235. (.pdf, 2.1mb)

Ramirez RL & Spear LP (2010). Ontogeny of ethanol-induced motor impairment following acute ethanol: assessment via the negative geotaxis reflex in adolescent and adult rats. Pharmacol Biochem Behav, 95:242-248. (.pdf, 510kb)

Doremus-Fitzwater TL & Spear LP (2010). Age-related differences in amphetamine sensitization: effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats. Pharmacol Biochem Behav, 96:198-205. (

Hennessy MB, Deak T & Schiml-Webb PA (2010). Early attachment-figure separation and increased risk for later depression: potential mediation by proinflammatory processes. Neurosci Biobehav Rev, 34:782-790. (

Nichols AJ & Olson EC (2010). Reelin promotes neuronal orientation and dendritogenesis during preplate splitting. Cereb Cortex, 20:2213-2223. (.pdf, 3.1mb)

Siebert JR, Middleton FA & Stelzner DJ (2010). Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury. BMC Neuroscience, 11:148-165. (.pdf, 2.2mb)

Arias C, Pautassi RM, Molina JC & Spear NE (2010). A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.. Dev Psychobiol, 52:545-557. (

Morales RS, Molina JC, Spear NE & Abate P (2010). Participation of the endogenous opioid system in the acquisition of a prenatal ethanol-related memory: effects on neonatal and preweanling responsiveness to ethanol. Physiol Behav, 10:153-160. (.pdf, 93kb)

Acevedo MB, Molina JC, Nizhnikov ME, Spear NE & Pautassi RM (2010). High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence. Dev Psychobiol, 52:424-440. (.pdf, 841kb)

Eade AM, Sheehe PR & Youngentob SL (2010). Ontogeny of the enhanced fetal-ethanol-induced behavioral and neurophysiological olfactory response to ethanol odor. Alcohol Clin Exp Res, 34: 1705-13. (

Miller SS & Spear NE (2010). Mere odor exposure learning in the rat neonate immediately after birth and 1 day later. Dev Psychobiol, 52:343-351. (

Eade AM & Youngentob SL (2010). The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats. Alcohol Clin Exp Res, 34: 1705-13. (

Arias C, Molina JC & Spear NE (2010). Differential role of micro, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Physiol Behav, 99:348-354. (

Varlinskaya EI & Spear LP (2010). Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science? Dev Psychobiol, 52:236-243. (

Doremus-Fitzwater TL, Varlinskaya EI & Spear LP (2010). Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn, 72:114-123. (

Varlinskaya EI & Spear LP (2010). Sensitization to social anxiolytic effects of ethanol in adolescent and adult Sprague-Dawley rats after repeated ethanol exposure. Alcohol, 44:99-110. (.pdf, 49kb)

Laiosa MD, Mills JH, Lai Z-W, Singh KP, Middleton FA, Gasiewicz TA & Silverstone AE (2010). Identification of stage specific gene modulation during early thymocyte development by whole genome profiling analysis following Aryl hydrocarbon receptor activation. Mol Pharmacol, 77:773-783. (