Publications

2020

Bergstrom, H.C. (2020). Assaying fear memory discrimination and generalization:  Methods and  concepts. Current Protocols in Neuroscience, 91(1): e89. PMID: 31995285 PMCID: PMC7000165 (avail on 2021-03-01) doi: 10.1002/cpns.89

Datta, U., Schoenrock, S.E., Bubier, J.A., Bogue, M.A., Jentsch, J.D., Logan, R.W., Tarantino, L.M. & Chesler, E.J. (2020). Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.  Genes, Brain and Behavior, 19(3): e12645. PMID: 32012419 PMCID: PMC7060801 doi: 10.1111/gbb.12645

Doremus-Fitzwater, T.L., Youngentob, S.L., Youngentob, L., Gano, A., Vore, A.S. & Deak, T. (2020). Lingering effects of prenatal alcohol exposure on basal and ethanol-evoked expression of inflammatory-related genes in the CNS of adolescent and adult rats.  Frontiers in Behavioral Neuroscience, 14:82. PMID: 32714160 PMCID: PMC7344178 doi: 10.3389/fnbeh.2020.00082

Gano, A., Prestia, L., Middleton, F.A., Youngentob, S.L., Ignacio, C. & Deak, T. (2020). Gene  expression profiling reveals a lingering effect of prenatal alcohol exposure on inflammatory genes during adolescence and adulthood.  Cytokine, 133:155126.  PMID: 32505093 PMCID: PMC7387206 (avail 2021/9/1) doi: 10.1016/j.cyto.2020.155126

Landin, J.D., Gore-Langton, J.K., Varlinskaya, E.I., Spear, L.P. & Werner, D.F. (2020). General  anesthetic exposure during early adolescence persistently alters ethanol responses.  Alcoholism: Clinical and Experimental Research, 44(3): 611-19. PMID: 32068904 PMCID: PMC7069780 (avail 2021/3/2021)  doi: 10.1111/acer.14291

Lovelock, D.F. & Deak, T. (2020). Acute stress imposed during adolescence has minimal effects  on hypothalamic-pituitary-adrenal (HPA) axis sensitivity in adulthood in female Sprague-Dawley rats.  Physiology & Behavior, 213: 112707. PMID: 31634523 PMCID: PMC6885129 (avail on 2021-01-01) doi: 10.1002/dev21912

Sangha, S., Diehl, M.M., Bergstrom, H.C. & Drew, M.R. (2020). Know safety, no fear.  Neuroscience and Biobehavioral Reviews, 108: 218-230. PMID: 31738952 PMCID: PMC6981293 (avail on 2021-01-01) doi: 10.1016/j.neubiorev.2019.11.006

Savage, L.M., Toledo-Nunes, P., Gursky, Z.H., Milbocker, K.A. & Klintsova, A.Y. (2020). Midline thalamic damage associated with alcohol-use disorders: disruption of distinct thalamocortical pathways and function. Neuropsychology Review. PMID: 32789537 doi: 10.1007/s11065-020-09450-8

Spear, L.P. (2020). Timing eclipses amount: The critical importance of intermittency in alcohol  exposure effects.  Alcoholism: Clinical and Experimental Research, 44(4): 806-13. PMID: 32056231 PMCID: PMC7362729 (available on 2021-04-01) doi: 10.1111/acer.14307

Tang, S., Xu, S., Zhu, W., Gullapalli, R.P. & Mooney, S.M. (2020). Alterations in the whole brain  network organization after prenatal ethanol exposure. European Journal of Neuroscience, 51(10): 2110-18. PMID: 31855302 PMCID: PMC7211128 (avail on 2021-05-01) doi: 10.1111/ejn.14653

Towner, T.T., Fager, M. & Spear, L.P. (2020). Adolescent, but not adult, Sprague-Dawley rats display goal-directed responding after reward devaluation.  Developmental Psychobiology, 62(3): 368-79. PMID: 31493315 doi: 10.1002/dev.21912

Towner, T.T. & Varlinskaya, E.I. (2020). Adolescent ethanol exposure: Anxiety-like behavioral alterations, ethanol intake, and sensitivity.  Frontiers in Behavioral Neuroscience, 14: 45. PMID: 32296315 PMCID: PMC7136472 doi: 10.3389/fnbeh.2020.00045

Varlinskaya, E.I., Johnson, J.M., Przybysz, K.R., Deak, T. & Diaz, M.R. (2020). Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.  Progress in Neuropsychopharmacology & Biological Psychiatry, 98: 109812. PMID: 31707090 PMCID: PMC6920550 doi: 10.1016/j.pnpbp.2019.109812

2019

Barney, T.M., Vore, A.S., Gano, A., Mondello, J.E. & Deak, T. (2019). The influence of central interleukin-6 on behavioral changes associated with acute alcohol intoxication in adult male rats. Alcohol, 79: 37-45. PMID: 30472309 PMCID: PMC6531375 doi: 10.1016/j.alcohol.2018.11.004

Deak, T. & Savage, L.M. (2019). Setting the stage for understanding alcohol effects in late aging: A special issue including both human and rodent studies.  International Review of Neurobiology, 148: xiii-xxv. PMID: 31733669 PMCID: PMC6998208 doi: 10.1016/S0074-7742(19)30116-3

Galaj, E., Kipp, B.T., Floresco, S.B. & Savage, L.M. (2019). Persistent altearations of accumbal cholinergic interneurons and cognitive dysfunction after adolescent intermittent ethanol exposure. Neuroscience, 404: 153-64. PMID: 30742967 PMCID: PMC6459752 doi: 10.1016/j.neuroscience.2019.01.062

Gano, A., Vore, A.S., Sammakia, M.N. & Deak, T. (2019). Assessment of extracellular cytokines in the hippocampus of the awake behaving rat using large-molecule microdialysis combined with multiplex arrays after cute and chronic ethanol exposure. Alcoholism: Clinical and Experimental Research, 43(4): 640-54. PMID: 30667526 PMCID: 6443416 doi: 10.1111/acer.13963

Gano, A., Mondello, J.E., Doremus-Fitzwater, T.L. & Deak, T. (2019). Rapid alterations in neuroimmune gene expression after acute ethanol: timecourse, sex differences, and sensitivity to cranial surgery.  Journal of Neuroimmunology, 337: 577083. PMID: 31675629 PMCID: PMC6866658 doi: 10.1016/j.neuroim.2019.577083

Gano, A., Pautassi, R.M., Doremus-Fitzwater, T.L., Barney, T.M., Vore, A.S. & Deak, T. (2019). Conditioning the neuroimmune response to ethanol using taste and environmental cues in adolescent and adult rats.  Experimental Biology & Medicine, 244(5): 362-71. PMID: 30808184 PMCID: PMC6488863 doi: 10.1177/1535370219831709

Gore-Langton, J. & Spear, L.P. (2019). Prenatal ethanol exposure attenuates sensitivity to the aversive effects of ethanol in adolescence and increases adult preference for a 5% ethanol solution in males, but not females. Alcohol, 79: 59-69. PMID: 30597200 PMCID: PMC6692249 [avail 2020/9/1] doi: 10.1016/j.alcohol.2018.12.004

Hosova, D. & Spear, L.P. (2019). Voluntary elevated ethanol consumption in adolescent Sprague-Dawley rats: procedural contributors to age-specificity. Alcohol, 78: 1-12. PMID: 30797832 PMCID: PMC6612312 [avail 2020/8/1] doi: 10.1016/j.alcohol.2019.02.003

Landin, J.D., Palac, M., Carter, J.M., Dzumaga, Y., Santerre-Anderson, J.L., Fernandez, G.M., Savage, L.M., Varlinskaya, E.I., Spear, L.P., Moore, S.D., Swartzwelder, H.S., Fleming, R.L. & Werner, D.F. (2019). General anesthetic exposure in adolescent rats causes persistent maladaptions in cogntive and affective behaviors and neuroplasticity. Neuropharmacology, 150: 153-63. PMID: 30926450 doi: 10.1016/j.neuropharm.2019.03.022

 Lovelock, D.F. & Deak, T. (2019). Acute stress imposed during adolescence yields heightened anxiety in Sprague-Dawley rats that persists into adulthood: Sex differences and potential involvement of the medial amygdala. Brain Research, 1723: 146392. PMID: 31446016 PMCID: PMC6766421 [avail 2020/11/15] doi: 10.1016/j.brainres.2019.146392

 Ma, Y.Y. (2019). Striatal morphological and functional alterations induced by prenatal alcohol exposure. Pharmacological Research, 142: 262-66. PMID: 30807863 doi: 10.1016/j.phrs.2019.02.022

Perkins, A.E., Varlinskaya, E.I. & Deak, T. (2019). From adolescence to late aging: a comprehensive review of social behavior, alcohol and neuroinflammation across the lifespan.  International Review of Neurobiology, 148: 231-303.  PMID: 31733665 PMCID: PMC7265136 doi: 10.1016/bs.irn.2019.08.001

Saalfield, J. & Spear, L.P. (2019). Fos activation patterns related to acute ethanol and conditioned taste aversion in adolescent and adult rats. Alcohol, 78: 57-69. PMID: 30797833 PMCID: PMC6612301 doi: 10.1016/j.alcohol.2019.02.004

Shan, L., Galaj, E. & Ma, Y.Y. (2019). Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety. Neuropsychopharmacology, 44: 1886-95.

Toledo-Nunes, P., Kipp, B.T., Reitz, N.L. & Savage, L.M. (2019). Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction.  International Review of Neurobiology, 148: 101-68. PMID: 31733663 doi:10.1016/bs.irn.2019.09.002

Toledo-Nunes, P., Vedder, L.C., Deak, T. & Savage, L.M. (2019). A privotal role for thiamine deficiency in the expression of neuroinflammmation markers in models of alcohol-related brain damage. Alcoholism: Clinical and Experimental Research, 43(3): 425-38. PMID: 30589435 PMCID: PM6397077 doi: 10.1111/acer.13946

Varlinskaya, E.I., Miller, J., Deak, T. & Diaz, M.R. (2019). Adolescent forced swim stress increases social anxiety-like behaviors and alters the dynoprhin/kappa opioid receptor system in the basolateral amygdala of males. Progress in Neuropsychophamracology & Biological Psychiatry, 98(2): 109812. PMID: 31707090 doi: 10.1016/j.prnpbp.2019.109812

 Wang, D., Enck, J., Howell, B.W. & Olson, E.C. (2019). Ethanol exposure transiently elevates but persistently inhibits tyosine kinase activity and impairs the growth of the nascent apical dendrite. Molecular Neurobiology, 56(8): 5749-62. PMID: 30674037 PMCID: PMC6615985 [avail 2020/8/1] doi: 10.1007/s12035-019-1473-x

2018

Diaz MR, Przybysz KR, Rouzer SK. Age as a factor in stress and alcohol interactions: A critical role for the kappa opioid system. Alcohol. 2018 Nov;72:9-18. doi: 10.1016/j.alcohol.2017.10.002. Epub 2017 Oct 12. Review. PubMed PMID: 30322483.

Lovelcok, D.F. & Deak, T. (2018). Neuroendocrine and neuroimmune adaptation to Chronic Escalating Distress (CED): A novel model of chronic stress. Neurobiology of Stress, 9: 74-83. PMID: 30450375 PMCID: PMC6234279 doi: 10.1016/j.ynstr.2018.08.007

Perkins AE, Vore AS, Lovelock D, Varlinskaya E, Deak T. Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats. Pharmacol Biochem Behav. 2018 Aug 29;175:1-9. doi: 10.1016/j.pbb.2018.07.012. [Epub ahead of print] PubMed PMID: 30171932.

Russell AL, Tasker JG, Lucion AB, Fiedler J, Munhoz CD, Wu TJ, Deak T. Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease. J Neuroendocrinol. 2018 Oct;30(10):e12641. doi: 10.1111/jne.12641. Epub 2018 Oct 7. Review. PubMed PMID: 30144202; PubMed Central PMCID: PMC6181794.

Surkin PN, Brenhouse H, Deak T, Liberman AC, Lasaga M. Stress, alcohol and infection during early development: A brief review of common outcomes and mechanisms. J Neuroendocrinol. 2018 Oct;30(10):e12602. doi: 10.1111/jne.12602. Epub 2018 Aug 7. Review. PubMed PMID: 29682808; PubMed Central PMCID: PMC6181762.

Mooney SM, Varlinskaya EI. Enhanced sensitivity to socially facilitating and anxiolytic effects of ethanol in adolescent Sprague Dawley rats following acute prenatal ethanol exposure. Alcohol. 2018 Jun;69:25-32. doi: 10.1016/j.alcohol.2017.11.002. Epub 2017 Nov 6. PubMed PMID: 29571047; PubMed Central PMCID: PMC5936665.

Doremus-Fitzwater TL, Paniccia JE, Gano A, Vore AS, Deak T. Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes. Brain Behav Immun. 2018 May;70:141-156. doi: 10.1016/j.bbi.2018.02.009. Epub 2018 Feb 17. PubMed PMID: 29458194; PubMed Central PMCID: PMC5953812.

Popoola DO, Cameron NM. Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males. Dev Psychobiol. 2018 May;60(4):380-394. doi: 10.1002/dev.21607. Epub 2018 Feb 14. PubMed PMID: 29442358.

Akinmboni TO, Davis NL, Falck AJ, Bearer CF, Mooney SM. Excipient exposure in very low birth weight preterm neonates. J Perinatol. 2018 Feb;38(2):169-174. doi: 10.1038/jp.2017.165. Epub 2017 Nov 2. PubMed PMID: 29095430; PubMed Central PMCID: PMC5790602.

Varlinskaya, E.I., Spear, L.P. & Diaz, M.R. (2018). Stress alters social behavior and sensitivity to pharmacological activation of kappa opioid receptors in an age-specific manner in Sprague-Dawley rats. Neurobiology of Stress, 9: 124-32. PMID: 30450378 PMCID: PMC6234253 doi: 10.1101/399758

2017

Rouzer SK, Cole JM, Johnson JM, Varlinskaya EI, Diaz MR. Moderate Maternal
Alcohol Exposure on Gestational Day 12 Impacts Anxiety-Like Behavior in
Offspring. Front Behav Neurosci. 2017 Sep 29;11:183. doi:
10.3389/fnbeh.2017.00183. eCollection 2017. PubMed PMID: 29033803; PubMed Central
PMCID: PMC5626811.

Lovelock DF, Deak T. Repeated exposure to two stressors in sequence
demonstrates that corticosterone and paraventricular nucleus of the hypothalamus
interleukin-1β responses habituate independently. J Neuroendocrinol. 2017
Sep;29(9). doi: 10.1111/jne.12514. PubMed PMID: 28803453; PubMed Central PMCID:
PMC5617797.

Deak T, Kudinova A, Lovelock DF, Gibb BE, Hennessy MB. A multispecies approach
for understanding neuroimmune mechanisms of stress. Dialogues Clin Neurosci. 2017
Mar;19(1):37-53. Review. PubMed PMID: 28566946; PubMed Central PMCID: PMC5442363.

Vore AS, Doremus-Fitzwater T, Gano A, Deak T. Adolescent Ethanol Exposure
Leads to Stimulus-Specific Changes in Cytokine Reactivity and
Hypothalamic-Pituitary-Adrenal Axis Sensitivity in Adulthood. Front Behav
Neurosci. 2017 May 4;11:78. doi: 10.3389/fnbeh.2017.00078. eCollection 2017.
PubMed PMID: 28522965; PubMed Central PMCID: PMC5415566.

Gano A, Doremus-Fitzwater TL, Deak T. A cross-sectional comparison of
ethanol-related cytokine expression in the hippocampus of young and aged Fischer
344 rats. Neurobiol Aging. 2017 Jun;54:40-53. doi:
10.1016/j.neurobiolaging.2017.01.025. Epub 2017 Mar 17. PubMed PMID: 28319836;
PubMed Central PMCID: PMC5401774.

Fernandez GM, Lew BJ, Vedder LC, Savage LM. Chronic intermittent ethanol
exposure leads to alterations in brain-derived neurotrophic factor within the
frontal cortex and impaired behavioral flexibility in both adolescent and adult
rats. Neuroscience. 2017 Apr 21;348:324-334. doi:
10.1016/j.neuroscience.2017.02.045. Epub 2017 Feb 28. PubMed PMID: 28257889;
PubMed Central PMCID: PMC5458357.

Gano A, Pautassi RM, Doremus-Fitzwater TL, Deak T. Conditioned effects of
ethanol on the immune system. Exp Biol Med (Maywood). 2017 Apr;242(7):718-730.
doi: 10.1177/1535370217694097. Epub 2017 Jan 1. PubMed PMID: 28201924; PubMed
Central PMCID: PMC5363694.

Spencer RL, Deak T. A users guide to HPA axis research. Physiol Behav. 2017
Sep 1;178:43-65. doi: 10.1016/j.physbeh.2016.11.014. Epub 2016 Nov 18. Review.
PubMed PMID: 27871862; PubMed Central PMCID: PMC5451309.

2016

Dannenhoffer CA & Spear LP (2016). Age differences in conditioned place preferences and taste aversions to nicotine. Developmental Psychobiology, 58(5): 660-66. doi: 10.1002/dev.21400. PMID: 27027859  (http://onlinelibrary.wiley.com/doi/10.1002/dev.21400/epdf)

Diaz MR, Mooney SM & Varlinskaya EI (2016). Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats. Behavioural Brain Research, 310: 11-19. doi: 10.1016/j.bbr.216.05.003. PMID: 27154534 (http://ac.els-cdn.com/S0166432816302698/1-s2.0-S0166432816302698-main.pdf?_tid=b6765d4a-3fda-11e7-993a-00000aab0f02&acdnat=1495559605_9f5cee1ffe97c4b5708fd5d53e202d19)

Doremus-Ftizwater TL & Spear LP (2016). Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals. Special Issue: The Adolescent Brain, Neuroscience and Biobehavioral Reviews, 70: 121-34. doi: 10.1016/j.neubiorev.2016.08.015. PMID: 27524639
(http://ac.els-cdn.com/S0149763416303499/1-s2.0-S0149763416303499-main.pdf?_tid=2166ca16-3fdd-11e7-993a-00000aab0f02&acdnat=1495560643_ff9c2c26f4525da1aedeaa0286218a4e)

Eade AM, Youngentob LM and Youngentob SL (2016). The interaction of ethanol ingestion and social interaction with an intoxicated peer on the odor-mediated response to the drug in adolescent rats. Alcoholism: Clinical and Experimental Research, 40: 734-42. doi: 10.1111/acer.13009. PMID: 26996455 PMCID: PMC4820360  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820360/pdf/nihms753126.pdf)

Fernandez G, Stewart W & Savage LM (2016). Chronic drinking during adolescence predisposes the adult rat for continued heavy drinking: Neurotrophin and behavioral adaptation after long-term, continuous ethanol exposure. PLoS One, 11(3): e0149987. PMID: 26930631 PMCID: 4773001 doi: 10.1371/journal.pone.014987 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773001/pdf/pone.0149987.pdf)

Fernandez M, Fabio MC, Miranda-Morales RS, Virgolini MB, DeGiovanni LN, Acevedo MB, Hansen C, de Olmos S, Willie-Billie A, Nizhnikov ME, Spear LP & Pautassi RM (2016). Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response. Alcohol, 51: 89-100. doi: 10.1016/j.alcohol.2015.11.009. PMID: 26830848  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123306/pdf/nihms-751430.pdf)

Gano A, Doremus-Fitzwater TL & Deak T (2016). Sustained alterations in neuroimmune gene expression after daily, but not intermittent alcohol exposure. Brain Research, 1646: 62-72. doi: 10.1016/j.brainres.2016.05.027. (http://ac.els-cdn.com/S000689931630381X/1-s2.0-S000689931630381X-main.pdf?_tid=ba404138-414d-11e7-8dc3-00000aab0f01&acdnat=1495718955_08f9d0d86895c98481ce123b7d9823b5)

Nizhnikov, M.E., *Popoola. D.O. and Cameron, N.M. (2016) Transgenerational transmission of the effect of gestational ethanol exposure on ethanol use-related behavior. Alcoholism: Clinical and Experimental Research, 40(3), 497-506. PMID: 26876534 (http://onlinelibrary.wiley.com/doi/10.1111/acer.12978/epdf)

Saalfield J & Spear LP (2016). The ontogeny of ethanol aversion. Physiology & Behavior, 156: 164-70. doi: 10.1016/j.physbeh.2016.01.011. PMID: 26774181 PMCID: PMC4753083  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753083/pdf/nihms755552.pdf)

Spear LP (2016). Alcohol consumption in adolescence: A translational perspective. Current Addiction Reports, 3: 50-61. doi: 10.1007/s40429-016-0088-9.

Spear LP (2016). Consequences of adolescent use of alcohol and other drugs: Studies using rodent models. Neuroscience and Biobehavioral Reviews, 70: 228-43. doi: 10.1016/j.neubiorev.2016.07.026 (http://www.sciencedirect.com/science/article/pii/S0149763416304304)

2015

Bordner K, Deak T (2015). Endogenous opioids as substrates for ethanol intake in the neonatal rat: The impact of prenatal ethanol exposure on the opioid family in the early postnatal period. Physiology & Behavior, 148: 100-10. doi: 10.1016/j.physbeh.2015.02.013. PMID: 25662024 (PDF)

Deak T, Hunt PS (2015). Early ontogeny as a unique developmental epoch for learning, memory and consequences of alcohol exposure: a Festschrift to honor the work of Dr. Norman E. Spear. Physiology & Behavior, 148:1-5. PMID: 26066730 doi: 10.1016/j.physbeh.2015.03.020. (PDF)

Deak T, Quinn M, Cidlowski JA, Murphy AZ & Sheridan JF (2015). Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for stress-related disease. Stress, 18(4): 367-80. doi: 10.3109/10253890.2015.1053451. PMID: 26176590 PMCID: PMC4813310 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813310/pdf/nihms769249.pdf)

Doremus-Fitzwater TL, Gano A, Paniccia JE, Deak T (2015). Male adolescent rats display blunted cytokine responses in the CNS after acute ethanol or lipopolysaccharide exposure. Physiology & Behavior, 148: 131-44. doi: 10.1016/j.physbeh.2015.02.032. PMID: 25708278 (PDF)

Ignacio C, Hicks SD, Burke P, Lambert L, Szombathyne-Meszaros Z & Middleton FA (2015). Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain. BMC Neuroscience, 16:55. doi: 10.1186/s12868-015-0195-x. PMID: 26341662 PMCID: PMC4560885 (PDF)

Savage LM (2015). Alcohol related brain damage and neuropathology. Chapter 7, In (Eds: Svanberg J, Withall A, Draper B & Bowden S). Alcohol and the Adult Brain, Taylor & Francis, Psychological Press, East Sussex, UK. 108-125.

Spear LP (2015). Adolescent alcohol exposure: Are there separate vulnerable periods within adolescence? Physiology & Behavior, 148: 122-30. doi: 10.1016/j.physbeh.2015.01.027. PMID: 2564108 (PDF)

2014

Olson EC (2014). Analysis of preplate splitting and early cortical development illuminates the biology of neurological disease. Frontiers in Pediatrics, 2:121. Doi: 10.3389/fped.2014.00121. PMCID: PMC4227491 (PDF)

Camargo MD, Ignacio C, Burke P, Middleton FA (2015). Alcohol intake and apoptosis: A review and examination of molecular mechanisms in the central nervous system. In V. Patel (Ed) Molecular Nutrition: Alcohol, Elsevier, New York.

Ignacio C, Mooney SM, Middleton FA (2014). Effects of acute prenatal exposure to ethanol on microRNA expression are ameliorated by social enrichment. Frontiers in Pediatrics, 2:13. doi: 10.3389/fped.2014.00103. PMCID: PMC 4173670 (PDF)

Mantella NM, Youngentob SL (2014). Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. PLoS One, 9(7):e10225. doi: 10.1371/journal.pone.0102255. PMCID: PMC41000884 PDF)

Anderson RI & Spear LP (2014). Age differences in ethanol discrimination: acquisition and ethanol dose generalization curves following multiple training conditions in adolescent and adult rats. Alcohol Clin Exp Res, 38(1): 186-94. (http://onlinelibrary.wiley.com/doi/10.1111/acer.12255/pdf)

Fabio MC, Nizhnikov ME, Spear NE & Pautassi RM (2014). Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. Dev Psychobiol, 56(3): 574-83. (http://onlinelibrary.wiley.com/doi/10.1002/dev.21101/pdf)

Morales M, Schatz KC, Anderson RI, Spear LP & Varlinskaya EI (2014). Conditioned taste aversion to ethanol in a social context: Impact of age and sex. Behav Brain Res, 261: 323-27. (http://ac.els-cdn.com/S0166432813007973/1-s2.0-S0166432813007973-main.pdf?_tid=365990a0-592d-11e4-9fbc-00000aab0f01&acdnat=1413901324_bde3422b69dd441295b18d731e238199)

Nizhnikov ME, Pautassi RM, Carter JM, Landin JD, Varlinskaya EI, Bordner KA, Werner DF & Spear NE (2014). Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62, 066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression. Alcohol Clin Exp Res, 38(6): 1630-38. (http://onlinelibrary.wiley.com/doi/10.1111/acer.12416/pdf)

Miranda-Morales RS, Nizhnikov ME & Spear NE (2014). Prenatal exposure to ethanol during late gestation facilitates operant self-administration of the drug in 5-day-old rats. Alcohol, 48(1): 25-33. (http://ac.els-cdn.com/S074183291300205X/1-s2.0-S074183291300205X-main.pdf?_tid=3a649ec0-587d-11e4-be08-00000aacb361&acdnat=1413825740_105bc6118af60bf7bc6ecd88b9f4bd7c)

Spear LP (2013). Adolescents and alcohol: Acute sensitivities, enhanced intake, and later consequences. Neurotoxicol, Teratol, 41: 51-59. (http://ac.els-cdn.com/S0892036213002225/1-s2.0-S0892036213002225-main.pdf?_tid=beaa9252-592c-11e4-a766-00000aacb361&acdnat=1413901124_cccfef4287fef12c97ca9ed4f7da958f)

Fabio MC, March SM, Molina JC, Nizhnikov ME, Spear NE & Pautassi RM (2013). Prenatal ethanol exposure increases ethanol intake and reduces C-fos expression in infralimbic cortex of adolescent rats. Pharmacol Biochem Behav, 103(4): 842-52. (http://ac.els-cdn.com/S0091305712003334/1-s2.0-S0091305712003334-main.pdf?_tid=6f91d690-587c-11e4-8408-00000aab0f26&acdnat=1413825399_4ef45b42f5bf1a53f3c6c39ae358296f)

Morales M, Varlinskaya EI & Spear LP (2013). Anxiolytic effects of the GABAa receptor partial agonist, L-838,417: Impact of age, test context familiarity, and stress. Pharmacol Biochem Behav, 109: 31-37. (http://ac.els-cdn.com/S0091305713001202/1-s2.0-S0091305713001202-main.pdf?_tid=56458522-5883-11e4-90bb-00000aacb35e&acdnat=1413828364_4ed3a373a9bac3d868d9ab71f18f0c88)

2013

Acevedo MB, Nizhnikov M, Spear NE, Molina JC & Pautassi RM (2013). Ethanol-induced locomotor activity in adolescent rats and relationships with ethanol-induced conditioned place preference and conditioned taste aversion. Dev Psychobiol, 55(4): 429-42. (http://onlinelibrary.wiley.com/doi/10.1002/dev.21048/pdf)

Anderson RI, Morales M, Spear LP & Varlinskaya EI (2013). Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats. Psychopharmacology (Berl), 231(8): 1687-93. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760984/)

Morales M, Anderson RI, Spear LP & Varlinskaya EI (2013). Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. Dev Psychobiol, 56(4): 700-12. (http://onlinelibrary.wiley.com/doi/10.1002/dev.21137/pdf)

Kozlov AP, Nizhnikov ME, Kramskaya TA, Varlinskaya EI & Spear NE (2013). Mu-opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation. Pharmacol Biochem Behav, 103(4): 773-782. (http://ac.els-cdn.com/S009130571200319X/1-s2.0-S009130571200319X-main.pdf?_tid=d10737fa-4f06-11e4-9198-00000aacb360&acdnat=1412785322_6bc6a56a73c1192efc04acdf4c50dcb1)

Morales M, Varlinskaya EI & Spear LP (2013). Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats. Behav Brain Res, 250: 18-22. (https://www.ncbi.nlm.nih.gov/pubmed/23651880)

Nichols A., OÕDell R., Powrozek TA & Olson EC (2013). Ex utero electroporation and whole hemisphere explants: a simple method for studies of early cortical development. J Vis Exp, 3: 74. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643163/pdf/jove-74-50271.pdf

Morales M & Spear LP (2013). The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats. Psychopharmacology, (https://www.ncbi.nlm.nih.gov/pubmed/24043344)

Anderson RI, Bush PC & Spear LP (2013). Environmental manipulations alter age differences in attribution of incentive salience to reward-paired cues. Behav Brain Res, 257: 83-89. (http://ac.els-cdn.com/S0166432813005718/1-s2.0-S0166432813005718-main.pdf?_tid=22706718-592c-11e4-a323-00000aab0f02&acdnat=1413900862_ce15754fe615b23c40d6100d4c09300c)

2012

Acevedo MB, Nizhnikov ME, Spear NE, Molina JC & Pautassi RM (2012). Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion. Dev Psychobiol, 55(4): 429-42. (http://onlinelibrary.wiley.com/doi/10.1002/dev.21048/pdf)

Powrozek TA & Olson EC (2012). Ethanol-induced disruption of Golgi apparatus morphology, primary neurite number and cellular orientation in developing cortical neurons. Alcohol, 46: 619-27. (https://www.ncbi.nlm.nih.gov/pubmed/22840816)

Pautassi RM, Nizhnikov ME, Fabio MC & Spear NE (2012). Early maternal separation affects ethanol-induced conditioning in a nor-BNI insensitive manner, but does not alter ethanol-induced locomotor activity. Pharmacol Biochem Behav,100(3): 630-638. (http://ac.els-cdn.com/S0091305711003601/1-s2.0-S0091305711003601-main.pdf?_tid=3a2f441e-4f04-11e4-9044-00000aab0f27&acdnat=1412784210_2bdd23a0111bfe36c9e3e1a47788d646)

Anderson RI, Agoglia AE, Morales M, Varlinskaya EI & Spear LP (2012). Stress, kappa manipulations, and aversion effects of ethanol in adolescent and adult male rats. Neuroscience, 249: 214-22. (http://ac.els-cdn.com/S030645221201216X/1-s2.0-S030645221201216X-main.pdf?_tid=67e64b94-587f-11e4-a4a2-00000aab0f02&acdnat=1413826675_321a6178022774f7973ef94dd13682d9)

Pautassi RM, Nizhnikov ME & Spear NE (2012). Ethanol-mediated appetitive conditioning in infant rats, but not corticosterone release, is dependent on route of ethanol administration. Dev Psychobiol, 54(1): 98-104. (http://onlinelibrary.wiley.com/doi/10.1002/dev.20567/pdf)

Pautassi RM, Nizhnikov ME, Spear NE & Molina JC (2012). Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement. Alcohol, 46(6): 585-593. (http://ac.els-cdn.com/S0741832912000900/1-s2.0-S0741832912000900-main.pdf?_tid=28c989e8-4f07-11e4-a6ca-00000aab0f6b&acdnat=1412785469_15663784441627ab241109cab54b27bc)

Cameron DA, Middleton FA, Chenn A & Olson EC (2012). Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development. BMC Neurosci, 13(1): 90. (http://www.biomedcentral.com/content/pdf/1471-2202-13-90.pdf)

Glendinning JI, Simons YM, Youngentob L & Youngentob SL (2012). Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats. Exp Biol Med (Maywood), 237(3): 236-240. (.pdf, 905kb)

Hicks SD, Lewis L, Ritchie J, Burke P, Abdul-Malak Y, Adackpara N, Canfield K, Shwarts E, Gentile K, Meszaros ZS & Middleton FA (2012). Evaluation of cell proliferation, apoptosis, and dna-repair genes as potential biomarkers for ethanol-induced cns alterations. BMC Neurosci, 13(1): 128. (.pdf, 1.9mb)

Kozlov AP, Nizhnikov ME, Varlinskaya EI, & Spear NE (2012). The role of social isolation in ethanol effects on the preweanling rat. Behav Brain Res, 227(1): 43-57. (.pdf, 2.6mb)

Meszaros ZS, Dimmock JA, Ploutz-Snyder R, Chauhan SV, Abdul-Malak Y, Middleton FA & Batki SL (2012). Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder. Schizophr Res, 132(2-3): 190-193. (.pdf, 303kb)

Middleton FA, Varlinskaya EI &Mooney SM (2012). Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment. Dev Neurosci, 34(2-3): 115-128. (http://www.karger.com/Article/Pdf/337858)

Middleton FA, Varlinskaya EI & Mooney SM (2012). Behavioral and molecular effects of acute prenatal exposure to ethanol are altered by social enrichment. Alcohol Clin Exp Res Supplement.

Miranda-Morales RS, Molina JC, Spear NE & Abate P (2012). Naloxone attenuation of ethanol-reinforced operant responding in infant rats in a re-exposure paradigm. Psychopharmacology (Berl) 219(1): 235-246. (http://link.springer.com/article/10.1007%2Fs00213-011-2402-5)

Pautassi RM, Nizhnikov ME, Acevedo MB & Spear NE (2012). Early role of the kappa opioid receptor in ethanol-induced reinforcement. Physiol Behav 105(5): 1231-1241. (http://ac.els-cdn.com/S0031938412000157/1-s2.0-S0031938412000157-main.pdf?_tid=0ea78878-4f0a-11e4-9375-00000aab0f6b&acdnat=1412786714_fdd56653b6b2975a4021a7b7ff6d9b4f)

Nizhnikov ME, Pautassi RM, Varlinskaya EI, Rahmani P, & Spear NE (2012). Ontogenetic differences in ethanol's motivational properties during infancy. Alcohol, 46(3): 225-234. (http://ac.els-cdn.com/S0741832912000183/1-s2.0-S0741832912000183-main.pdf?_tid=617748d6-4f0a-11e4-96a9-00000aacb35e&acdnat=1412786853_c3863bf04cf6a083c3bde3659d0d14c5)

Powrozek TA & Olson EC (2012). Ethanol-induced disruption of Golgi apparatus morphology, primary neurite number and cellular orientation in developing cortical neurons. Alcohol, 46(7): 619-627, 2012. (http://ac.els-cdn.com/S0741832912001279/1-s2.0-S0741832912001279-main.pdf?_tid=f70e614a-4f0a-11e4-88b0-00000aab0f26&acdnat=1412787104_b7c38e5b4181d49bfb17e89716ee620c)

Varlinskaya EI, Vogt BA & Spear LP (2012). Social context induces two unique patterns of c-Fos expression in adolescent and adult rats.  Dev Psychobiol, 55(7): 684-97, 2012. (http://onlinelibrary.wiley.com/doi/10.1002/dev.21064/pdf)

Youngentob SL, Kent PF & Youngentob LM (2012). Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol. Exp Biol Med (Maywood), 237(10): 1197-1208. (.pdf, 558kb)

2011

Arias C & Spear NE (2011). Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats. Pharmacol Biochem Behav, 100(1): 81-85. (.pdf, 643kb)

Mooney SM & Varlinskaya EI (2011). Acute prenatal exposure to ethanol and social Behav Brain Res, 216(1): 358-364. (.pdf, 610kb)

Pautassi RM, Myers M, Spear LP, Molina JC & Spear NE (2011). Ethanol induces second-order aversive conditioning in adolescent and adult rats. Alcohol, 45(1): 45-55. (.pdf, 422kb)

Pautassi RM, Nizhnikov ME, Acevedo MB & Spear NE (2011). Naloxone blocks ethanol-mediated appetitive conditioning and locomotor activation in adolescent rats. Behav Brain Res, 216(1): 262-269. (.pdf, 94kb)

Pautassi RM, Nizhnikov ME, Fabio MC & Spear NE (2011). An acetaldehyde-sequestering agent inhibits appetitive reinforcement and behavioral stimulation induced by ethanol in preweanling rats. Pharmacol Biochem Behav, 97(3): 462-469. (.pdf, 352kb)

Pautassi RM, Nizhnikov ME, Truxell E, Varlinskaya EI & Spear NE (2011). Ontogeny of ethanol intake in alcohol preferring (P) and alcohol nonpreferring (NP) rats. Dev Psychobiol, 53(3): 234-245. (.pdf, 1.2mb)

Ponce LF, Pautassi RM, Spear NE & Molina JC (2011). Maternal care alterations induced by repeated ethanol leads to heightened consumption of the drug and motor impairment during adolescence: a dose-response analysis. Physiol Behav, 103(5): 477-486. (http://ac.els-cdn.com/S0031938411000825/1-s2.0-S0031938411000825-main.pdf?_tid=d0b184e6-4f0a-11e4-8561-00000aab0f6c&acdnat=1412787039_8ba5037207a7c30ee7aa0990f946f814)

Pueta M, Rovasio RA, Abate P, Spear NE & Molina JC (2011). Prenatal and postnatal ethanol experiences modulate consumption of the drug in rat pups, without impairment in the granular cell layer of the main olfactory bulb.  Physiol Behav, 102(1): 63-75. (.pdf, 2.2mb)

Ramirez RL, Varlinskaya EI & Spear LP (2011). Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. Alcohol Clin Exp Res, 35(6): 1149-1159. (.pdf, 479kb)

Spear LP (2011). Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data. Dev Cogn Neurosci, 1(4): 392-400. (.pdf, 345kb)

Robinson DL, Zitzman DL, Smith KJ & Spear LP (2011). Fast dopamine release events in the nucleus accumbens of early adolescent rats. Neuroscience, 176:296-307. (.pdf, 230kb)

Pautassi RM, Myers M, Spear LP, Molina JC & Spear NE (2011). Ethanol induces second-order aversive conditioning in adolescent and adult rats. Alcohol, 45:45-55. (.pdf, 409kb)

Broadwater M, Varlinskaya EI & Spear LP (2011). Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. Alcohol Clin Exp Res, 35:1392-1403. (.pdf, 1.4mb)

2010

Varlinskaya EI, Doremus-Fitzwater TL & Spear LP (2010). Repeated restraint stress alters sensitivity to the social consequences of ethanol in adolescent and adult rats. Pharmacol Biochem Behav, 96:228-235. (.pdf, 2.1mb)

Ramirez RL & Spear LP (2010). Ontogeny of ethanol-induced motor impairment following acute ethanol: assessment via the negative geotaxis reflex in adolescent and adult rats. Pharmacol Biochem Behav, 95:242-248. (.pdf, 510kb)

Doremus-Fitzwater TL & Spear LP (2010). Age-related differences in amphetamine sensitization: effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats. Pharmacol Biochem Behav, 96:198-205. (http://ac.els-cdn.com/S0091305710001413/1-s2.0-S0091305710001413-main.pdf?_tid=838c849e-4f0b-11e4-bc14-00000aab0f02&acdnat=1412787339_27d8de8d4b043f827e9a3213d7c3097c)

Hennessy MB, Deak T & Schiml-Webb PA (2010). Early attachment-figure separation and increased risk for later depression: potential mediation by proinflammatory processes. Neurosci Biobehav Rev, 34:782-790. (http://ac.els-cdn.com/S0149763409000463/1-s2.0-S0149763409000463-main.pdf?_tid=b1507980-4f0b-11e4-a930-00000aacb361&acdnat=1412787416_9ef74f900c47b9e7afea3fa5cb81314f)

Nichols AJ & Olson EC (2010). Reelin promotes neuronal orientation and dendritogenesis during preplate splitting. Cereb Cortex, 20:2213-2223. (.pdf, 3.1mb)

Siebert JR, Middleton FA & Stelzner DJ (2010). Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury. BMC Neuroscience, 11:148-165. (.pdf, 2.2mb)

Arias C, Pautassi RM, Molina JC & Spear NE (2010). A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.. Dev Psychobiol, 52:545-557. (http://onlinelibrary.wiley.com/doi/10.1002/dev.20460/pdf)

Morales RS, Molina JC, Spear NE & Abate P (2010). Participation of the endogenous opioid system in the acquisition of a prenatal ethanol-related memory: effects on neonatal and preweanling responsiveness to ethanol. Physiol Behav, 10:153-160. (.pdf, 93kb)

Acevedo MB, Molina JC, Nizhnikov ME, Spear NE & Pautassi RM (2010). High ethanol dose during early adolescence induces locomotor activation and increases subsequent ethanol intake during late adolescence. Dev Psychobiol, 52:424-440. (.pdf, 841kb)

Eade AM, Sheehe PR & Youngentob SL (2010). Ontogeny of the enhanced fetal-ethanol-induced behavioral and neurophysiological olfactory response to ethanol odor. Alcohol Clin Exp Res, 34: 1705-13. (http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2009.01083.x/pdf)

Miller SS & Spear NE (2010). Mere odor exposure learning in the rat neonate immediately after birth and 1 day later. Dev Psychobiol, 52:343-351. (http://onlinelibrary.wiley.com/doi/10.1002/dev.20456/pdf)

Eade AM & Youngentob SL (2010). The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats. Alcohol Clin Exp Res, 34: 1705-13. (http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2010.01257.x/pdf)

Arias C, Molina JC & Spear NE (2010). Differential role of micro, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Physiol Behav, 99:348-354. (http://ac.els-cdn.com/S0031938409003722/1-s2.0-S0031938409003722-main.pdf?_tid=3cccee76-4f0c-11e4-a57d-00000aab0f6b&acdnat=1412787650_06ed0d0ba8460d55fe7f775a6e8e1782)

Varlinskaya EI & Spear LP (2010). Sensitivity to ethanol and other hedonic stimuli in an animal model of adolescence: implications for prevention science? Dev Psychobiol, 52:236-243. (http://onlinelibrary.wiley.com/doi/10.1002/dev.20457/pdf)

Doremus-Fitzwater TL, Varlinskaya EI & Spear LP (2010). Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn, 72:114-123. (http://ac.els-cdn.com/S0278262609001614/1-s2.0-S0278262609001614-main.pdf?_tid=8a3d9386-4f0c-11e4-b7e9-00000aab0f01&acdnat=1412787780_f6fc3f0d3f8f9b450d2b7d0c2b9c6235)

Varlinskaya EI & Spear LP (2010). Sensitization to social anxiolytic effects of ethanol in adolescent and adult Sprague-Dawley rats after repeated ethanol exposure. Alcohol, 44:99-110. (.pdf, 49kb)

Laiosa MD, Mills JH, Lai Z-W, Singh KP, Middleton FA, Gasiewicz TA & Silverstone AE (2010). Identification of stage specific gene modulation during early thymocyte development by whole genome profiling analysis following Aryl hydrocarbon receptor activation. Mol Pharmacol, 77:773-783. (http://molpharm.aspetjournals.org/content/77/5/773.full.pdf+html)