Summary of Research:
Movement is an ancient and basic function that is integral to the survival of the individual and species. As such, disorders of movement have a profound impact upon all facets of life. One of the most common movement disorders is Parkinson's disease, a neurodegenerative disorder that compromises dopaminergic areas of the brain rendering the individual unable to initiate, coordinate and execute movement. By employing animal models of Parkinson's disease and a combination of gene therapy, chemogenetic and neurochemical techniques, we examine the role of various neurocircuits and neurotransmitters responsible for this debilitating disorder. As importantly, we explore pharmacological targets within the brain that may aid in the development of more efficacious treatment for the Parkinsonian patient. Our projects, funded by the National Institutes of Health and various foundations investigate neuroplasticity in the movement systems that may provide a novel target for the reduction of Parkinsonian symptoms and side effects that occur as a result of chronic drug therapy.
I am both a mentor and scientist and I would have it no other way. It is not an exaggeration to say that my students are the secret to my success. Regardless of level, the mentor-mentee relationship is an active collaboration. Graduate students in my laboratory, through study and experience, will learn to expertly apply the scientific method to timely research questions accelerating their trajectory to confident, thoughtful and independent scientists. Under this mentorship model trainees will develop a multi-faceted investigational approach and master cutting-edge neuroscience techniques that will lead to the design, execution and communication of sound and innovative research. As part of this process, they are strongly encouraged to cross-train with other faculty, here and at other institutions, to foster collaborative acumen and diversify their technical skill set. I also encourage grant development and writing, so students can experience this process so critical to success in our field.
Representative Publications (+graduate student author, *undergraduate student author):
+Lanza, K., *Meadows, S.M., +Chambers, N., *Nuss, E., Deak, M.M., Ferré, S. and Bishop, C. (2018). Behavioral and Cellular Dopamine D1 and D3 Receptor-Mediated Synergy: Implications for L-DOPA-Induced Dyskinesia. Neuropharmacology 138:304-314. (PMID: 29936243)
+Conti, M.M., +Chambers, N. and Bishop, C. (2018). A new outlook on cholinergic interneurons in Parkinson’s disease and L-DOPA-induced dyskinesia. Neuroscience and Biobehavioral Reviews 92:67-82. (PMID: 29782883)
+Lindenbach, D.L., Das, B, +Conti, M.M., *Meadows, S.M., Aloke, D. and Bishop, C. (2017). D-512, a novel dopamine D2 / D3 receptor agonist, demonstrates superior anti-parkinsonian efficacy over ropinirole in parkinsonian rats. British Journal of Pharmacology 174(18):3058-3071. (PMID: 28667675).
*Meadows, S.M., +Chambers, N., +Conti, M.M., *Tasber, C., *Sheena, E., Varney, M., Newman-Tancredi, A. and Bishop, C. (2017). Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of L-DOPA-induced dyskinesia. Experimental Neurology 292:168-178. (PMID: 28342749).
+Lindenbach, D.L., +Conti, M.M., +Ostock, C., George, J., *Goldenberg, A., *Melikhov-Sosin, M., *Nuss, E. and Bishop, C. (2016). The role of primary motor cortex (M1) glutamate and GABA signaling in L-DOPA-induced dyskinesia in Parkinsonian rats. Journal of Neuroscience 36(38):9873-87. (PMID: 27656025).
- PhD, MA, Wayne State University
- BA, Hope College
- Parkinson's Disease
- Drug Development
- The Diseased Brain
- Experimental Psychology-Learning
- Movement Disorders Laboratory
- Clinical Neuroscience
- Faculty Recognition Award from Service for Students with Disabilities
- Dean’s Research Semester Award for Junior Faculty
- Phi Eta Sigma Faculty Award
- Stagner Memorial Award for outstanding research
- State University of New York Chancellor’s Award for Excellence in Teaching
Bishop Laboratory Webpage Link: https://cbishoplab.wordpress.com/Bishop Laboratory Google Scholar Link: https://scholar.google.com/citations?user=Cgnm6uoAAAAJ&hl=en