President's Report Masthead
March 31, 2018

New research could lead to improved method of treating pancreatic cancer

A heating and freezing process known as dual thermal ablation can kill pancreatic cancer cells, according to new research from Binghamton University.

The collaborative study, conducted by researchers from academia and industry and funded by grants from the National Cancer Institute, used pancreatic cancer cells to investigate the effect of heating and freezing on cell death. The research was conducted by Robert Van Buskirk and John Baust, professors of biological sciences and directors at Binghamton University’s Institute of Biomedical Technology, and Kenneth Baumann, a graduate student studying biology.

“How do we solve the problem of pancreatic cancer when it comes to trying to get rid of the tumor, when chemo and radiation just simply doesn’t work?” said Van Buskirk. “The whole idea is, can one come up with a different surgical intervention that’s less invasive and more effective?

“In order to figure that out, you can commercially obtain pancreatic cancer cells and grow them on specialized plasticware,” Van Buskirk said. “The basic question is, are both freezing and heat in combination more effective than freezing or heat alone? If you freeze pancreatic cancer cells like you do in cryoablation, a lot of them die, but some will survive and regrow. If you heat them, they’ll die, but again some will come back. But with dual-thermal ablation, for reasons that we do not yet understand, more die and don’t come back. In fact, over time, cells that survive the initial insult continue to die.”

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